精神分裂症相关单核苷酸多态性调控microRNA功能研究进展

doi:10.16288/j.yczz.19-126

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (8): 677-685.doi: 10.16288/j.yczz.19-126

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Schizophrenia-associated single nucleotide polymorphisms affecting microRNA function

Wenquan Liang¹,Yu Hou²,Cunyou Zhao¹()

^1. Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
^2. Department of Pediatric Neurology, Affiliated BaYi Children's Hospital, PLA Army General Hospital, Beijing 100700, China

Received:2019-05-08 Revised:2019-07-07 Online:2019-08-20 Published:2019-08-05
Contact: Zhao Cunyou E-mail:cyzhao@smu.edu.cn
Supported by:
Supported by the Guangdong Science and Technology Foundation(2019B030316032);The Guangzhou Science and Technology Foundatio(201804010259);The National Natural Science Foundation of China(81601175);The National Natural Science Foundation of China(81671333)

Abstract

Abstract:

MicroRNAs (miRNAs) compose a class of non-coding transcripts with a mean length of 22 nucleotides, and play critical roles in regulating gene expression in the process of development, proliferation and differentiation of neurons. Recent genome-wide association studies (GWAS) find most of schizophrenia-associated single nucleotide polymorphisms (SNPs) locating in the non-coding regions, providing functional implications of miRNAs in the development of schizophrenia. In this review, we highlight the interplays between GWAS-SNPs and miRNAs in four perspectives: SNP in miRNA gene; miRNA located in the host gene; SNP located in the miRNA’s seed sequence; SNP located in the miRNA’s binding site. We also speculate on the future research on the role of miRNA in the development of schizophrenia.

Key words: GWAS, SNP, miRNA, schizophrenia

Wenquan Liang,Yu Hou,Cunyou Zhao. Schizophrenia-associated single nucleotide polymorphisms affecting microRNA function[J]. Hereditas(Beijing), 2019, 41(8): 677-685.

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