“喝酒脸红”基因探秘——遗传学实验案例深度挖掘与应用探讨

doi:10.16288/j.yczz.25-002

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Hereditas(Beijing) ›› 2025, Vol. 47 ›› Issue (10): 1169-1175.doi: 10.16288/j.yczz.25-002

• Genetics Teaching • Previous Articles

Exploring the gene of “alcohol flush”——in-depth exploration and application of genetic experimental cases

Xueying Zhao¹^,²(), You Li², Daru Lu², Yan Pi¹^,²()

1. National Demonstration Center for Experimental Biology Education, Fudan University, Shanghai 200433, China
2. School of Life Sciences, Fudan University, Shanghai 200433, China

Received:2025-01-02 Revised:2025-01-17 Online:2025-10-20 Published:2025-04-18
Contact: Yan Pi E-mail:xueying_zhao@fudan.edu.cn;yanpi@fudan.edu.cn
Supported by:
2022 Shanghai Municipal-level Key Courses Construction Project for Higher Education Institutions(19);2023 Fudan University Curriculum Ideological and Political Education Teaching Reform Research Project-Genetics Experiment(IAH6222054/096)

Abstract

Abstract:

Genetic related technologies are increasingly influencing human health and life. From theory to practice, teaching through typical cases of disciplinary applications has become a popular new model in the field of genetics education. This experiment takes the phenotype case of “alcohol flush” as an example, organically integrating genetic knowledge from multiple perspectives and levels such as phenotypic analysis, population genetic analysis and pedigree analysis with experimental cases. In teaching practice, the “alcohol flush” case study can greatly stimulate students’ interest in active learning, cultivate students’ ability to connect theory with practice, discover and solve problems from practice, and further expand their learning of genetic testing related bioethics, genetic information protection, genetic resource protection, and other knowledge through personal practical teaching, thus cultivate students’ scientific thinking ability and scientific literacy.

Key words: ADH1B, ALDH2, genetic experiment, bioethics

Xueying Zhao, You Li, Daru Lu, Yan Pi. Exploring the gene of “alcohol flush”——in-depth exploration and application of genetic experimental cases[J]. Hereditas(Beijing), 2025, 47(10): 1169-1175.

Figures/Tables 6

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基因/基因型	人数	频率*
T/T	114	0.50
C/T	91	0.40
C/C	22	0.097
T	/	0.71
C	/	0.31

基因/基因型	人数	频率*
G/G	146	0.68
A/G	68	0.32
A/A	6	0.028
G	/	0.82
A	/	0.17

位点	东亚人群	南亚人群	非洲人群	欧洲人群	美洲人群
rs1229984	0.31	0.024	0.0011	0.029	0.060
rs671	0.18	0	0.00060	0	0.0030

Exploring the gene of “alcohol flush”——in-depth exploration and application of genetic experimental cases

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