纤毛微管蛋白翻译后修饰及其与纤毛病相关的研究进展

doi:10.16288/j.yczz.25-121

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Hereditas(Beijing) ›› 2026, Vol. 48 ›› Issue (2): 142-157.doi: 10.16288/j.yczz.25-121

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Progress on posttranslational modifications of ciliary tubulin and association with ciliopathies

Zitao Peng(), Jiongchen Lin, Haibo Xie()

Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China

Received:2025-05-04 Revised:2025-07-10 Online:2026-07-29 Published:2025-07-29
Contact: Haibo Xie E-mail:zitaoPeng1006@163.com;xiehaibo@ouc.edu.cn
Supported by:
National Nature Science Foundation of China(32470856)

Abstract

Abstract:

Cilia are hair-like structures protruding from the surface of eukaryotic cells, composed of a microtubule-based cytoskeleton and bounded by ciliary membrane, which play a crucial role in organ development and homeostasis maintenance in organisms. The ciliary tubulin undergoes several highly conserved posttranslational modifications (PTMs) including acetylation, glutamylation, glycylation and detyrosination. The studies indicate that ciliary tubulin PTMs are adequate to precisely regulate the fine tuning of assembly/disassembly, maintenance, motility, and signaling of cilia. Dysregulated ciliary tubulin PTMs leads to ciliary dysfunction, strongly implicated in human disorders including ciliopathies. Here, we review the current understanding how ciliary tubulin PTMs regulate cilia formation and function, with a focus on their association with human disorders, which may provide novel avenues for therapeutic intervention in ciliopathies.

Key words: cilia, tubulin posttranslational modifications, dysfunction, ciliopathies

Zitao Peng, Jiongchen Lin, Haibo Xie. Progress on posttranslational modifications of ciliary tubulin and association with ciliopathies[J]. Hereditas(Beijing), 2026, 48(2): 142-157.

Figures/Tables 2

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Progress on posttranslational modifications of ciliary tubulin and association with ciliopathies

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