染色质相关RNA的m6A修饰调控染色质可及性与基因转录研究进展

doi:10.16288/j.yczz.25-129

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Hereditas(Beijing) ›› 2025, Vol. 47 ›› Issue (11): 1186-1196.doi: 10.16288/j.yczz.25-129

• Review • Previous Articles Next Articles

Advances of m⁶A modification of chromatin-associated RNAs regulating chromatin accessibility and gene transcription

Jialin Ren(), Yize Tong, Rui Cai()

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

Received:2025-05-07 Revised:2025-07-22 Online:2025-11-20 Published:2025-08-18
Contact: Rui Cai E-mail:renjl@nwafu.edu.cn;cairui1663@nwafu.edu.cn
Supported by:
National Natural Science Foundation of China(32202642);Earmarked Fund for(CARS-35-PIG)

Abstract

Abstract:

Chromatin-associated RNAs (caRNAs), closely related to chromatin structure and functions, are a class of RNAs that interact with chromatin in cis, trans, or cis-trans cooperation modes, regulating gene expression and maintaining the orderly progression of cellular processes. N⁶-methyladenosine (m⁶A) is a ubiquitous and dynamically reversible epigenetic modification in eukaryotic RNAs, playing an important regulatory role in a variety of biological processes. m⁶A modification of chromatin-associated RNAs can regulate chromatin accessibility and gene expression at the transcriptional level, maintaining the normal functions of organisms. In this review, we summarize the mechanisms of m⁶A-modified caRNAs-chromatin interactions and their role in gene expression, with the aim of providing scientific basis and ideas for the analysis of the molecular mechanisms of gene transcriptional regulation.

Key words: chromatin-associated RNAs, m⁶A modification, chromatin accessibility, transcriptional regulation

Jialin Ren, Yize Tong, Rui Cai. Advances of m⁶A modification of chromatin-associated RNAs regulating chromatin accessibility and gene transcription[J]. Hereditas(Beijing), 2025, 47(11): 1186-1196.

Figures/Tables 2

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caRNAs	m⁶A机制	m⁶A水平	功能	参考文献
新生RNA(包括pre-mRNA、 PROMPTs、eRNA)	METTL3; METTL14; WTAP	上调	促进新生RNA的合成及有效转录	[24]
pre-mRNA Sxl	MTC; YTHDC1	下调	影响果蝇性别分化	[25]
lncRNA XIST	METTL3; YTHDC1	上调	促进X染色质的失活	[26]
lncRNA XIST	METTL14; YTHDF2	上调	促进lncRNA XIST降解	[27]
circRNA	METTL3; METTL14; YTHDF3; FTO	上调	驱动并增强circRNA的翻译	[33]
U6 snRNA	METTL16	上调	影响剪接体的组装或识别	[28,31]
重复RNA LINE1	METTL3; YTHDC1; FTO	上调/下调	调控LINE1的生命周期与转座以及基因组中LINE1相邻基因的表达	[35]
carRNAs(包括paRNA、eRNA、重复RNA)	METTL3; YTHDC1	上调/下调	调控carRNAs的稳定性以及染色质状态和下游基因表达	[37]

Advances of m⁶A modification of chromatin-associated RNAs regulating chromatin accessibility and gene transcription

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