WRKY transcription factors that are unique to plants are the new type transcriptional regulatory factors in which N-terminal ends contain a conserved WRKYGQR amino acids sequences. WRKY transcription factors regulate the target genes expression that contain the W-box elements in the promoter regions by specifically binding to (T)(T)TGAC(C/T) sequence. Therefore, the WRKY transcription factors participate in the plant various kinds defense responses and regulate the plant growth and development. This article reviews the progress of the basic structure and biological function of plant WRKY transcription factors.