Case report of a rare platelet-specific antigen HPA-10bw allele found in Chinese mainland
1. Shanghai Blood Center, Shanghai 200051, China;
2. National Institutes of Health, Bethesda, MD 20892, USA
Received date: 2006-06-01
Revised date: 2006-07-20
Online published: 2007-02-10
A total of 1,000 Chinese blood donors were typed for human platelet antigens (HPA) using a sequence specific primers -polymerase chain reaction (PCR-SSP) based HPA genotyping method. An individual with a rare HPA-10w(a+b+) genotype was found. In order to confirm the typing results, a fragment of HPA-10 gene was amplified by PCR and then sequenced. Sequencing data showed that a single G to A substitution at nucleotide 263 occurred, resulting in amino acid change from Arg(CGA) to Gln(CAA) at position 62 of GPⅢa protein. The substitution generated antigenic specificity HPA-10bw. The detection of an HPA-10bw allele in the Chinese population suggests that this rare allele should be considered in platelet alloimmunization, such as neonatal alloimmune thrombocytopenia (NAIT), post-transfusion thrombocytopenic purpura (PTP) and post-transfusion refractoriness to platelets (PTR).
FENG Ming-Liang, SHEN Tong, HUANG Hui, SHEN Wei, WANG Jian-Lian, LIU Da-Zhuang, ZHAO Tong-Mao . Case report of a rare platelet-specific antigen HPA-10bw allele found in Chinese mainland[J]. Hereditas(Beijing), 2007 , 29(2) : 177 -177―179 . DOI: 10.1360/yc-007-0177
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