Genetic co-adaptability of colony gene bank is formed in the process of system evolvement, and it is a part of the attribute of gene bank, just as the gene frequency of every locus. With the genetic co-adaptability of loci combination under the condition of genetic disequilibrium, the genesis evolution and the system status of colony could be analyzed; through the study of genetic co-adaptability, the veracity of the economy character mark could be improved. We summarized about the concept, the basic and the actuality of genetic co-adaptability.