This study was to explore the relationships between ^-511T>C and ⁺³⁹⁵⁴C>T single nucleotide polymorphisms(SNP) in IL-1b gene with lumbar intervertebral disc disease. We analyzed ^-511T>C and ⁺³⁹⁵⁴C>T SNP in IL-1b gene by the polymerase chain reaction-restriction fragment length polymorphism and electrophoresis methods respectively in 81 cases with lumbar disc disease and 101 healthy controls. The relationship between ^-511T>C and ⁺³⁹⁵⁴C>T SNP in IL-1b gene and lumbar disc disease in two groups was measured, so does the relationship between ^-511T>C and ⁺³⁹⁵⁴C>T SNP in IL-1b gene and intervertebral disc degeneration in those younger than 45-year-old. The results showed there were ^-511T>C and ⁺³⁹⁵⁴C>T SNP in IL-1b gene. There was a significant difference in the distribution of TT, TC and CC genotype or T, C genotype of -511T>C of IL-1b in two groups. And there was no significant difference in the distribution of ⁺³⁹⁵⁴C>T SNP in IL-1b gene in two groups. There was no significant difference between the distribution of ^-511T>C and ⁺³⁹⁵⁴C>T SNP in IL-1b gene and intervertebral disc degeneration in those younger than 45-year-old. It suggested ^-511T>C SNP in IL-1b gene be one of the susceptible alleles for Lumbar disc disease.