GT elements are DNA sequences occurred in tandem repeats in the promoter region of plant genes, which are rich in nucleotides T and A in promoters. A few GT elements and their functions have been characterized in different plants. Factors GT are transcription factors with trihelix motifs for DNA-binding domains and specific binding to GT elements. Presently, GT factors are only observed in plants. The interaction of GT factors and GT elements can regulate the transcrip-tion of related genes and improve resistance of plants or involve in plant morphogenesis. In this article, we summarized the discover, structure, and interaction of GT factors and GT elements.