BMPs belong to the transforming growth factor-b superfamily. BMPs have been proved to have extensive bio-logical functions in mammals, including growth regulation, cell proliferation and differentiation. More and more evidence has shown that BMPs play a key role in fertility, especially in folliculogenesis in female mammals. Smad proteins are intra-cellular signaling transduction molecules of BMP family, which can transduce the BMP signal from the cell membrane to the nucleus. In this review, BMPs, BMP/Smad-related signal transduction and the regulation of BMP activity were summa-rized, and the regulatory roles of BMP/Smad signal transduction pathway in folliculogenesis were discussed.
WANG Wei, WANG Shao-Bing, XU Yin-Xue
. Signal transduction of BMP/Smad and its relationship with mammalian folliculogenesis[J]. Hereditas(Beijing), 2009
, 31(3)
: 245
-254
.
DOI: 10.3724/SP.J.1005.2009.00245
