Aging or tumor: the crosstalk between telomerase and p53

ZHANG Xiu-Feng, TANG Wen-Ru, LUO Ying

doi:10.3724/SP.J.1005.2009.00451

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Hereditas(Beijing) >

2009 , Vol. 31 >Issue 5: 451 - 456

DOI: https://doi.org/10.3724/SP.J.1005.2009.00451

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Aging or tumor: the crosstalk between telomerase and p53

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Lab of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China

Received date: 2008-09-22

Revised date: 2008-11-07

Online published: 2009-05-10

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Abstract

Telomerase and p53 play critical roles in tumorigenesis and senescence. The mutation of p53 gene and the reac-tivation of telomerase have been found in most of the human tumors. Aiming telomerase and p53 genes have become im-portant strategies in tumor therapy. We reviewed the aging and tumor phenotype in different status of telomerase and p53 (mTR-/-p53+/+; mTR-/-P53-/-), which indicated that telomere dysfunction could initiate or suppress the tumorigenesis de-pending on the status of p53. This helps further understanding of the crosstalk between p53 and telomerase in aging and tumorigenesis, and provides a new idea for treating tumor.

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ZHANG Xiu-Feng, TANG Wen-Ru, LUO Ying . Aging or tumor: the crosstalk between telomerase and p53[J]. Hereditas(Beijing), 2009 , 31(5) : 451 -456 . DOI: 10.3724/SP.J.1005.2009.00451

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