In vivo delivery of siRNA

SHI Ming-Lei, ZHAO Zhi-Hu, WANG Yang, CHEN Hui-Peng

doi:10.3724/SP.J.1005.2009.00683

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Hereditas(Beijing) >

2009 , Vol. 31 >Issue 7: 683 - 689

DOI: https://doi.org/10.3724/SP.J.1005.2009.00683

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In vivo delivery of siRNA

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Beijing Institute of Biotechnology, Beijing 100071, China

Received date: 2008-10-30

Revised date: 2009-12-19

Online published: 2009-07-10

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Abstract

RNA interference (RNAi) is a mechanism of posttranscriptional gene silencing mediated by small interfering RNA (siRNA). The ability of synthetic siRNA to silence genes in vivo has made it well suited as therapeutic drug, but the instability and polarity of siRNA and the complexity of in vivo circumstances retarded rapid development of RNAi-based therapies. In this review, a summary of the advances on in vivo siRNA delivery is presented and discussed.

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SHI Ming-Lei, ZHAO Zhi-Hu, WANG Yang, CHEN Hui-Peng . In vivo delivery of siRNA[J]. Hereditas(Beijing), 2009 , 31(7) : 683 -689 . DOI: 10.3724/SP.J.1005.2009.00683

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