Utilization of Werner syndrome mouse model in studying premature aging and tumor

JIA Shu-Ting, YANG Shi-Hua, LUO Ying

doi:10.3724/SP.J.1005.2009.00785

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Hereditas(Beijing) >

2009 , Vol. 31 >Issue 8: 785 - 790

DOI: https://doi.org/10.3724/SP.J.1005.2009.00785

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Utilization of Werner syndrome mouse model in studying premature aging and tumor

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Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China

Received date: 2008-09-19

Revised date: 2009-04-16

Online published: 2009-08-10

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Abstract

Werner syndrome (WS) is a rare autosomal recessive genetic disease in human. It is considered as a good model disease in studying human premature syndrome. Werner protein (WRN) is a nuclear protein mutated in WS. Recent biochemical and genetic studies indicated that WRN plays important roles in DNA replication, DNA repair, and telomere maintenance. Here, we reviewed the molecular genetics of WS and the importance of telomere and WRN in the develop-ment of WS. Knocking out both telomerase and Wrn genes in mouse faithfully manifests human WS. The mouse model provides a unique genetic platform to explore the crosstalk of premature aging and tumor.

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JIA Shu-Ting, YANG Shi-Hua, LUO Ying . Utilization of Werner syndrome mouse model in studying premature aging and tumor[J]. Hereditas(Beijing), 2009 , 31(8) : 785 -790 . DOI: 10.3724/SP.J.1005.2009.00785

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