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Progress on horse genome project

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  • 1. College of Animal Science and Animal Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China; 
    2. Institute of Animal Science, Chinese Academy of Agricultural Science, Beijing 100193, China

Received date: 2009-08-06

  Revised date: 2009-10-19

  Online published: 2010-03-15

Abstract

There is unique genetic information belonging to various kinds of living beings. Understanding of the formation process of organisms and a variety of vital movement is associated with the achievements of genome study. As horse has a notable health condition and great record of the genealogy in the world, thus it becomes a valuable model animal for studying life science. Despite of a late start, the map of the horse genome has undergone unprecedented expansion during the last few years. The current progresses of the horse genome, including genetic map, physical map, comparative genomic map, and functional genomics, were reviewed in this paper. The maps are currently used worldwide to discover genes associated with various traits of significance in horse including general health, disease resistance, reproduction, fertility, athletic performance, phenotypic characteristics like coat color, etc. The results are believed to provide new ideas and approaches for prevention, diagnostics, and therapeutic for horses, and also better foundation of breed selection and equine genetic breeding.

Cite this article

YANG Gong, MA Ru-Hui, LI Bei, HUANG Lai . Progress on horse genome project[J]. Hereditas(Beijing), 2010 , 32(3) : 211 -218 . DOI: 10.3724/SP.J.1005.2010.00211

References

[1] Bowling AT, Breen M, Chowdhary BP, Hirota K, Lear T, Millon LV, Ponce de Leon FA, Raudsepp T, Stranzinger G. International system for cytogenetic nomenclature of the domestic horse. Report of the Third International Com-mittee for the Standardization of the domestic horse karyotype, Davis, CA, USA, 1996. Chromosome Res, 1997, 5(7): 433–443.

[2] Bugno M, S?ota E, Ko?cielny M. Karyotype evaluation among young horse populations in Poland. Schweiz Arch Tierheilkd, 2007, 149(5): 227–232.

[3] Bugno M, Zabek T, Golonka P, Pieńkowska-Schelling A, Schelling C, S?ota E. A case of an intersex horse with 63, X/64, XX/65, XX, del(Y)(q?) karyotype. Cytogenet Genome Res, 2008, 120(1–2): 123–126.

[4] Xu X, Arnason U. The complete mitochondrial DNA se-quence of the horse, Equus caballus: extensive heteroplasmy of the control region. Gene, 1994, 148(2): 357–362.

[5] George M Jr, Ryder OA. Mitochondrial DNA Evolution in the Genus Equus. Mol Biol Evol, 1986, 3(6): 535–546.

[6] Chowdhary BP, Raudsepp T. The horse genome. Genome Dyn, 2006, 2: 97–110.

[7] Tozaki T, Swinburne J, Hirota K, Hasegawa T, Ishida N, Tobe T. Improved resolution of the comparative horse-human map: investigating markers with in silico and linkage map-ping approaches. Gene, 2007, 392(1-2): 181–186.

[8] Penedo MC, Millon LV, Bernoco D, Bailey E, Binns M, Cholewinski G, Ellis N, Flynn J, Gralak B, Guthrie A, Hasegawa T, Lindgren G, Lyons LA, Røed KH, Swinburne JE, Tozaki T. International Equine Gene Mapping Workshop Report: a comprehensive linkage map constructed with data from new markers and by merging four mapping resources. Cytogenet Genome Res, 2005, 111(1): 5–15.

[9] Swinburne JE, Boursnell M, Hill G, Pettitt L, Allen T, Chowdhary B, Hasegawa T, Kurosawa M, Leeb T, Mashima S, Mickelson JR, Raudsepp T, Tozaki T, Binns M. Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families. Genomics, 2006, 87(1): 1–29.

[10] Raudsepp T, Santani A, Wallner B, Kata SR, Ren C, Zhang HB, Womack JE, Skow LC, Chowdhary BP. A de-tailed physical map of the horse Y chromosome. Proc Natl Acad Sci USA, 2004, 101(25): 9321–9326.

[11] Raudsepp T, Gustafson-Seabury A, Durkin K, Wagner ML, Goh G, Seabury CM, Brinkmeyer-Langford C, Lee EJ, Agarwala R, Stallknecht-Rice E, Schäffer AA, Skow LC, Tozaki T, Yasue H, Penedo MC, Lyons LA, Khazanehdari KA, Binns MM, MacLeod JN, Distl O, Guérin G, Leeb T, Mickelson JR, Chowdhary BP. A 4,103 marker integrated physical and comparative map of the horse genome. Cytogenet Genome Res, 2008, 122(1): 28–36.

[12] Looft C, Paul S, Philipp U, Regenhard P, Kuiper H, Distl O, Chowdhary BP, Leeb T. Sequence analysis of a 212 kb defensin gene cluster on ECA 27q17. Gene, 2006, 376(2): 192–198.

[13] Müller D, Kuiper H, Mömke S, Böneker C, Drögemüller C, Swinburne JE, Binns M, Chowdhary BP, Distl O. Physical mapping of the ATP2A2 gene to equine chromosome 8p14→p12 by FISH and confirmation by linkage and RH map-ping. Cytogenet Genome Res, 2006, 114(1): 94G.

[14] Perelygin AA, Lear TL, Zharkikh AA, Brinton MA. Com-parative analysis of vertebrate EIF2AK2 (PKR) genes and assignment of the equine gene to ECA15q24-q25 and the bovine gene to BTA11q12-q15. Genet Sel Evol, 2006, 38(5): 551–563.

[15] Klukowska-Rötzler J, Bugno M, Sander P, Slota E, Dolf G, Chowdhary BP, Leeb T, Gerber V. Chromosomal assign-ment of the two candidate genes (EGFR, CLCA1) for equine recurrent airway obstruction (RAO) by FISH and RH mapping. Hereditas, 2006, 143(2006): 138–141.

[16] Prause A, Guionaud C

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