RUAN Jian, DU Wei-Dong . Male infertility and gene defects[J]. Hereditas(Beijing), 2010 , 32(5) : 411 -422 . DOI: 10.3724/SP.J.1005.2010.00411

[74] Rosengren KJ, Zhang S, Lin F, Daly NL, Scott DJ, Hughes RA, Bathgate RA, Craik DJ, Wade JD. Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3. J Biol Chem, 2006, 281(38): 28287–28295.

[75] Schöneberg T, Schulz A, Biebermann H, Hermsdorf T, Römpler H, Sangkuhl K. Mutant G-protein-coupled re-ceptors as a cause of human diseases. Pharmacol Ther, 2004, 104(3): 173–206.

[76] Ferlin A, Foresta C. The INSL3-LGR8 hormonal system in humans: Testicular descent, cryptorchidism and esticular functions. Curr Med Chem, 2005, 5(5): 421–430.

[77] 李建平, 钟影, 吴东. 隐睾及少精子症家系1例报告. 中华男科学杂志, 2004, 10(6): 472–473. [78] 蒋先镇. 男性不育症的诊断. 医学新知杂志, 2008, 18(1): 3–6.

[79] Aston KI, Carrell DT. Genome-wide study of sin-gle-nucleotide polymorphisms associated with azoosper-mia and severe oligozoospermia. J Androl, 2009, 30(6): 711–725.

[80] Matzuk MM, Lamb DJ. The biology of infertility: research advances and clinical challenges. Nat Med, 2008, 14(11): 1197–213.

[81] Simoni M, Bakker E, Krausz C. EAA/EMQN best practice guidelines for molecular diagnosis of Y chromosomal mi-crodeletions. State of the art 2004. Int J Androl, 2004, 27(4): 240–249.

[82] Yun YJ, Park JH, Song SH, Lee S. The association of 4a4b polymorphism of endothelial nitric oxide synthase (eNOS) gene with the sperm morphology in Korean infertile men. Fertil Steril, 2008, 90(4): 1126–1131.

[83] Zhang W, Zhang SZ, Xiao CY, Yang Y, Zhoucun A. Muta-tion screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men. Reproduction, 2007, 133(2): 511–516.

[84] Osborne EC, Lynch M, McLachlan R, Trounson AO, Cram DS. Microarray detection of Y chromosome deletions as-sociated with male infertility. Reprod Biomed Online, 2007, 15(6): 673–680.

[85] Zhu YJ, Liu SY, Wang H, Wei P, Ding XP. The prevalence of azoospermia factor microdeletion on the Y chromosome of Chinese infertile men detected by multi-analyte sus-pension array technology. Asian J Androl, 2008, 10(6): 873–881.

[86] Lee S, Joo HS, Lee SH,Park JE, Kim JM, Hwang JH, Cho KS, Hwang SY. Application of DNA chip techniques for Yq microdeletion analysis in infertile males. Exp Mol Med, 2004, 36(2): 179–184.

[87] 宋焱鑫. 男性不育非药物治疗概况. 中华实用中西医杂志, 2008, 21(8): 629–632.

[88] Sheehan M. Is gene therapy for the treatment of male in-fertility ethical? Nat Clin Pract Urol, 2008, 5(11): 596–597.

[89] Isidori A, Latini M, Romanelli F. Treatment of male infer-tility. Contraception, 2005, 72(4): 314–318.

[90] Nyboe Andersen A, Goossens V, Bhattacharya S, Fer-raretti AP, Kupka MS, de Mouzon J, Nygren KG. Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE: ESHRE. The European IVF Monitoring Pro-gramme (EIM), for the European Society of Human Re-production and Embryology (ESHRE). Hum Reprod, 2009, 24(6): 1267–1287.

[91] 唐智柳, 吕军, 董恒进, 应向华, 陈英耀. 我国人类辅助生殖技术开展现状及社会认识调查. 中华医院管理杂志, 2003, 19(3): 154–156.

[92] Woldringh GH, Janssen IM, Hehir-Kwa JY, van den Elzen C, Kremer JAM, de Boer P, Schoenmakers EF. Constitutional DNA copy number changes in ICSI chil-dren. Hum Reprod, 2009, 24(1): 233–240.

[93] Serebrovska ZA, Serebrovskaya TV, Pyle RL, Di Pietro ML. Transmission of male infertility and intracytoplasmic sperm injection (mini-review). Fiziol Zh, 2006, 52(3): 110–118.