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Recent Advance of Whole Genome Amplification and its Application prospect in Forensic Individual Identification

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  • 1. Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China; 2. Criminal investigation team, Kunming public security bureau, Kunming 650224, China

Received date: 2010-01-23

  Revised date: 2010-03-29

  Online published: 2010-11-25

Abstract

Whole genome amplification (WGA) is a technique that could non-selectively amplify the genomic DNA. In recent years, intensive studies have been made on application of WGA in trace DNA amplification, which might be applied to amplify trace DNA collected from crime scenes and provide enough DNA templates for forensic individual identification. However, the problem of amplification bias happened in the complicated test materials from real crime scenes is still troublesome. Development of WGA method with low amplification bias and high yield is the main target of current forensic research. Here, we reviewed the advances and the application prospect of WGA in individual identification. This might provide a reference for solving the problem of the amplification bias.

Cite this article

CA Hai-Jiang, LIU Hai-Chao, SHI Bin, LI An, TANG Wen-Ru, LUO Ying . Recent Advance of Whole Genome Amplification and its Application prospect in Forensic Individual Identification[J]. Hereditas(Beijing), 2010 , 32(11) : 1119 -1125 . DOI: 10.3724/SP.J.1005.2010.01119

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