Many studies have show that the structurally polymorphic Alu insertion within HLA class I region are useful tools for investigating the origin, evolution and recombination of HLA class I progenitor haplotypes and gene diversity in different ethnic populations. In the present study, we determined the frequencies of HLA-Alus (i.e., AluMICB, AluTF, AluHJ, AluHG, and AluHF) in Zhuang and Yugu ethnic populations at first. Then, combined with HLA genotyping data, we studied associations between HLA-Alus and HLA-A alleles in Zhuang, Yugu, Bulang, Dai, and Hani ethnic populations. Our results showed that (1) the frequencies of five HLA-Alus were 1.5%~35.8% and 9.2%~34.8% in Zhuang and Yugu, respectively; and (2) the results of association between HLA-A alleles and HLA-Alu showed strong association between AluHG insertion and HLA-A*02 subtypes in all populations, association between AluHJ insertion and HLA-A*2402 in all populations, and association between AluHJ insertion and HLA-A*1101, -A*2407 in Bulang. The present study suggested that the distribution of HLA-Alus as well as the associations between HLA-Alus and HLA class I alleles are variable in different ethnic populations. HLA Alus alone or together with the HLA class I alleles are informative genetic markers for the identi-fication of HLA class I allele and variation of haplotype lineages in different populations.
SHI Lei, TAO Yu-Feng, SHI Li, DAO Yu-Fen, XU Liang, HUANG Xiao-Qin, LIN Ke-Qi, YI Wen, SUN Gao, YANG Zhao-Qiang, CHU Jia-You
. Polymorphic Alu insertions and their associations with HLAⅠalleles in Yugu and Zhuang ethnic populations[J]. Hereditas(Beijing), 2011
, 33(2)
: 138
-146
.
DOI: 10.3724/SP.J.1005.2011.00138
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