Genomics is the core subject of “omics” theories and research methods in modern life science. Teaching of genomics has characteristics such as more content, more difficult points, higher demands on English and comprehensive expertise etc. We proposed the course system established for Genomics and summarized some experiences based on our teaching practice that emphasizes on increasing the study autonomy and course interactivity by group study on stimulating questions, innovative experiment, multi-media materials, and bilingual exercises etc.