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Advances in effector protein of histone methylation

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  • Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing 100191, China

Received date: 2010-09-25

  Revised date: 2010-12-20

  Online published: 2011-04-25

Abstract

As a significant epigenetic regulation mechanism, histone methylation plays an important role in many biological processes. In cells, there are various histone methyltransferases and histone demethylases working cooperatively to regulate the histone methylation state. Upon histone modification, effector proteins recognize modification sites specifically, and affect gene transcriptional process. This review mainly focuses on recent advances in histone methylation effector protein’s function mechanism.

Cite this article

SONG Bo-Xing, SHU Wei-Guo . Advances in effector protein of histone methylation[J]. Hereditas(Beijing), 2011 , 33(4) : 285 -292 . DOI: 10.3724/SP.J.1005.2011.00285

References

[1] Ruthenburg AJ, Allis CD, Wysocka J. Methylation of ly-sine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell, 2007, 25(1): 15-30.
[2] Kouzarides T. Chromatin modifications and their function. Cell, 2007, 128(4): 693-705.
[3] Watt F, Molloy PL. Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter. Genes Dev, 1988, 2(9):1136-1143.
[4] Zhu WG, Srinivasan K, Dai ZY, Duan WR, Druhan LJ, Ding HM, Yee L, Villalona-Calero MA, Plass C, Otterson GA. Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21Cip1 promoter. Mol Cell Biol, 2003, 23(12): 4056-4065.
[5] Barski A, Cuddapah S, Cui KR, Roh TY, Schones DE, Wang ZB, Wei G, Chepelev I, Zhao KJ. High-resolution profiling of histone methylations in the human genome. Cell, 2007, 129(4): 823-837.
[6] Vermeulen M, Mulder KW, Denissov S, Pijnappel WWM, van Schaik FMA, Varier RA, Baltissen MPA, Stunnenberg HG, Mann M, Timmers HTM. Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 ly-sine 4. Cell, 2007, 131(1): 58-69.
[7] Li HT, Ilin S, Wang W, Duncan EM, Wysocka J, Allis CD, Patel DJ. Molecular basis for site-specific read-out of his-tone H3K4me3 by the BPTF PHD finger of NURF. Nature, 2006, 442(7098): 91-95.
[8] Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J, Kauer M, Tackett AJ, Chait BT, Badenhorst P, Wu C, Allis CD. A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature, 2006, 442(7098): 86-90.
[9] Sims RJ, Millhouse S, Chen CF, Lewis BA, Erdjument-Bromage H, Tempst P, Manley JL, Reinberg D. Recognition of trimethylated histone H3 lysine 4 facili-tates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell, 2007, 28(4): 665-676.
[10] Shi XB, Gozani O. The fellowships of the INGs. J Cell Biochem, 2005, 96(6): 1127-1136.
[11] Hung T, Binda O, Champagne KS, Kuo AJ, Johnson K, Chang HY, Simon MD, Kutateladze TG, Gozani O. ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation. Mol Cell, 2009, 33(2): 248-256.
[12] Shi XB, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Peña P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Ku-tateladze TG, Shi Y, Côté J, Chua KF, Gozani O. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature, 2006, 442(7098): 96-99.
[13] Peña PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RPC, Subach OM, Champagne KS, Zhao R, Verkhusha VV, Li G, Gozani O, Kutateladze TG. Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J Mol Biol, 2008, 380(2): 303-312.
[14] Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen ZZ, Spooner E, Li E, Zhang GY, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell, 2006, 125(3): 467-481.
[15] Lan F, Collins RE, de Cegli R, Alpatov R, Horton JR, Shi XB, Gozani O, Cheng XD, Shi Y. Recognition of un-methylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature, 2007, 448(7154): 718-722.
[16] Motamedi MR, Hong EJE, Li X, Gerber S, Denison C, Gygi S, Moazed D. HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonover-lapping mechanisms. Mol Cell, 2008, 32(6): 778-790.
[17] Song K, Jung Y, Jung D, Lee I. Human Ku70 interacts with heterochromatin protein 1α. J Biol Chem, 2001, 276(11): 8321-8327.
[18] Wu LP, Wang X, Li L, Zhao Y, Lu SL, Yu Y, Zhou W, Liu XY, Yang J, Zheng ZX, Zhang H, Feng JN, Yang Y, Wang HY
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