Based on an analysis of the problems in teaching of genetics, we restructured the contents of genetics course to avoid overlapping with related courses and to establish a proper connection with other courses. It was suggested that reorganization of teaching contents of genetics by taking the genetic information as a main stream of the course would favor to make sure the integrity, systematicness, and features of genetics course. The current 25 chapters of genetics were organized into four domains of passage, storage, reading, and mutation (including replication) of genetic information. Each domain was designed to explain one aspect of the genetic information. In such a way the four domains could highly be tighten up. The overlapping parts with other courses were proposed to be abstracted for those descriptions of the movement and variation of genetic information. The courses centered by genetic information would have obvious features of genetics and be easier to be understood.