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Recent progress in heart regeneration

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  • 1. State Key Laboratory of Translational Cardiovascular Medicine, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China 2. Laboratory of Cardiovascular Development & Regeneration, Institute of Molecular Medicine, Peking University, Beijing 100871, China

Received date: 2010-12-23

  Revised date: 2011-03-23

  Online published: 2011-11-25

Abstract

Heart failure (CHF) is the direct cause of death of a variety of cardiovascular diseases, culminating in irreversible myocardial necrosis and fibrosis. Traditional drug treatment, intervention, and surgical treatment have their own limitations. Increasing cardiac regeneration and repair of the injured heart is undoubtedly a promising approach to solve these clinical problems. In this paper, we summarized recent progress of heart development and regeneration, highlighting potential involvement of cell proliferation, dedifferentiation and cell reprogramming. We also proposed several fundamental and important research directions in this exciting area.

Cite this article

ZHEN Yi-Song, HUI Ru-Tai, XIONG Jing-Wei . Recent progress in heart regeneration[J]. Hereditas(Beijing), 2011 , 33(11) : 1159 -1163 . DOI: 10.3724/SP.J.1005.2011.01159

References

[1] Thygesen K, Alpert JS, White HD. Joint ESC/ACCF/ AHA/WHF task force for the redefinition of myocardial infarction. Universal definition of myocardial infarction. J Am Coll Cardiol, 2007, 50(22): 2173-2195.
[2] 胡盛寿, 张浩. 再生医学-治疗心血管疾病的新途径. 心脑血管病防治, 2004, 4(3): 1-2.
[3] Hansson EM, Lindsay ME, Chien KR. Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell, 2009, 5(4): 364-377.
[4] Lepilina A, Coon AN, Kikuchi K, Holdway JE, Roberts RW, Burns CG, Poss KD. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regen-eration. Cell, 2006, 127(3): 607-619.
[5] Lengner CJ. iPS cell technology in regenerative medicine. Ann N Y Acad Sci, 2010, 1192(1): 38-44.
[6] Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. Direct reprogramming of fibro-blasts into functional cardiomyocytes by defined factors. Cell, 2010, 142(3): 375-386.
[7] Efe JA, Hilcove S, Kim J, Zhou HY, Ouyang KF, Wang G, Chen J, Ding S. Conversion of mouse fibroblasts into car-diomyocytes using a direct reprogramming strategy. Nat Cell Biol, 2011, 13(3): 215-222.
[8] Kikuchi K, Holdway JE, Major RJ, Blum N, Dahn RD, Begemann G, Poss KD. Retinoic Acid production by endocardium and epicardium is an injury response essential for ze-brafish heart regeneration. Dev Cell, 2011, 20(3): 397-404.
[9] Domian IJ, Chiravuri M, van der Meer P, Feinberg AW, Shi X, Shao Y, Wu SM, Parker KK, Chien KR. Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science, 2009, 326(5951): 426-429.
[10] Cai CL, Martin JC, Sun YF, Cui L, Wang LC, Ouyang KF, Yang L, Bu L, Liang XQ, Zhang XX, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM. A myocardial lineage derives from Tbx18 epicardial cells. Nature, 2008, 454(7200): 104-108.
[11] Ahuja P, Sdek P, MacLellan WR. Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol Rev, 2007, 87(2): 521-544.
[12] 王晓明, 臧益民, 高峰. 心肌细胞再生与心脏修复. 中华心血管病杂志, 2003, 31(9): 711-714.
[13] Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisén J. Evidence for cardiomyo-cyte renewal in humans. Science, 2009, 324(5923): 98-102.
[14] Bersell K, Arab S, Haring B, Kühn B. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell, 2009, 138(2): 257-270.
[15] Gao RL, Zhang J, Cheng LQ, Wu XS, Dong W, Yang XC, Li TC, Liu XF, Xu YB, Li XY, Zhou MD. A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recom-binant human neuregulin-1 in patients with chronic heart failure. J Am Coll Cardiol, 2010, 55(18): 1907-1914.
[16] Takeuchi JK, Bruneau BG. Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature, 2009, 459(7247): 708-711.
[17] Poss KD, Wilson LG, Keating MT. Heart regeneration in ze-brafish. Science, 2002, 298(5601): 2188-2190.
[18] Oberpriller JO, Oberpriller JC. Response of the adult newt ventricle to injury. J Exp Zool, 1974, 187(2): 249-259.
[19] Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, Evans T, Macrae CA, Stainier DYR, Poss KD. Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes. Nature, 2010, 464(7288): 601-605.
[20] Jopling C, Sleep E, Raya M, Martí M, Raya A, Belmonte JCI. Zebrafish heart regeneration occurs by cardiomyocyte dedif-ferentiation and proliferation. Nature, 2010, 464(7288): 606 -609.
[21] Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic β-cells are formed by self- duplication rather than stem-cell differentiation.
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