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Progresses on Neandertal genomics

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  • College of Life Science, Hebei Normal University, Shijiazhuang 050016, China

Received date: 2011-09-27

  Revised date: 2012-04-28

  Online published: 2012-06-25

Abstract

Neandertal is our closest known relative and also an archaic hominid reserving the richest fossils. Whether the Neandertals exchanged their DNA with modern human or not is a matter of debate on the modern human origin. The progresses on the mitochondrial and nuclear genomes of Neandertals in recent years were reviewed in this paper. Recent study has revealed possible genetic contribution of Neandertals to the modern human to some extent, which arose the rethinking of modern human origin. The experiences gained in the research on Neandertals will benefit the study on archaic hominids, unravel the mystery of modern human origin, and enrich the relative theoretical systems in evolutionary biological field.

Cite this article

BI Cai-Li, GUO Guang-Yan, ZHANG Xiao, TIAN Yan-Hui, SHEN Yin-Zhu . Progresses on Neandertal genomics[J]. Hereditas(Beijing), 2012 , 34(6) : 659 -665 . DOI: 10.3724/SP.J.1005.2012.00659

References

[1] Cann RL, Stoneking M, Wilson AC. Mitochondrial DNA and human evolution. Nature, 1987, 325(6099): 31-36.
[2] Stringer CB, Andrews P. Genetic and fossil evidence for the origin of modern humans. Science, 1988, 239(4845): 1263-1268.
[3] Wolpoff MH, Hawks J, Frayer DW, Hunley K. Modern human ancestry at the peripheries: a test of the replacement theory. Science, 2001, 291(5502): 293-297.
[4] Mellars P. Neanderthals and the modern human colonization of Europe. Nature, 2004, 432(7016): 461-465.
[5] Krings M, Stone A, Schmitz RW, Krainitzki H, Stoneking M, Pääbo S. Neandertal DNA sequences and the origin of modern humans. Cell, 1997, 90(1): 19-30.
[6] Krings M, Geisert H, Schmitz RW, Krainitzki H, Pääbo S. DNA sequence of the mitochondrial hypervariable region II from the Neandertal type specimen. Proc Natl Acad Sci USA, 1999, 96(10): 5581-5585.
[7] Krings M, Capelli C, Tschentscher F, Geisert H, Meyer S, von HaeselerA, Grossschmidt K, Possnert G, Paunovic M, Pääbo S. A view of Neandertal genetic diversity. Nat Genet, 2000, 26(2): 144-146.
[8] Currat M, Excoffier L. Modern humans did not admix with Neanderthals during their range expansion into Europe. PLoS Biol, 2004, 2(12): e421.
[9] Serre D, Langaney A, Chech M, Teschler-Nicola M, Paunovic M, Mennecier P, Hofreiter M, Possnert G, Pääbo S. No evidence of Neandertal mtDNA contribution to early modern humans. PLoS Biol, 2004, 2(3): e57.
[10] Green RE, Malaspinas AS, Krause J, Briggs AW, Johnson PLF, Uhler C, Meyer M, Good JM, Maricic T, Stenzel U, Prüfer K, Siebauer M, Burbano HA, Ronan M, Rothberg JM, Egholm M, Rudan P, Brajkovi? D, Ku?an ?, Guši? I, Wikström M, Laakkonen L, Kelso J, Slatkin M, Pääbo S. A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing. Cell, 2008, 134(3): 416-426.
[11] Briggs AW, Good JM, Green RE, Krause J, Maricic T, Stenzel U, Lalueza-Fox C, Rudan P, Brajkovic D, Kucan ?, Guši? I, Schmitz R, Doronichev VB, Golovanova LV, de la Rasilla M, Fortea J, Rosas A, Pääbo S. Targeted retrieval and analysis of five Neandertal mtDNA genomes. Science, 2009, 325(5938): 318-321.
[12] Lalueza-Fox C, Rosas A, Estalrrich A, Gigli E, Campos PF, García-Tabernero A, García-Vargas S, Sánchez-Quinto F, Ramírez O, Civit S, Bastir M, Huguet R, Santamaría D, Gilbert MTP, Willerslev E, de la Rasilla M. Genetic evi-dence for patrilocal mating behavior among Neandertal groups. Proc Natl Acad Sci USA, 2011, 108(1): 250-253.
[13] Mellars PA, French JC. Tenfold population increase in western Europe at the Neandertal-to-Modern human transition. Science, 2011, 333(6042): 623-627.
[14] Weaver TD, Roseman CC, Stringer CB. Close correspon-dence between quantitative- and molecular-genetic diver-gence times for Neandertals and modern humans. Proc Natl Acad Sci USA, 2008, 105(12): 4645-4649.
[15] Jorde LB, Watkins WS, Bamshad MJ, Dixon ME, Ricker CE, Seielstad MT, Batzer MA. The distribution of human genetic diversity: a comparison of mitochondrial, auto-somal, and Y-chromosome data. Am J Hum Genet, 2000, 66(3): 979-988.
[16] Currat M, Excoffier L. Modern humans did not admix with Neanderthals during their range expansion into Europe. PLoS Biol, 2004, 2(12): e421.
[17] Hawks J, Wolpoff MH. Paleoanthropology and the popu-lation genetics of ancient genes. Am J Phys Anthro-pol, 2001, 114(3): 269-272.
[18] Relethford JH. Absence of regional affinities of Neander-tal DNA with living humans does not reject multiregional evolution. Am J Phys Anthropol, 2001, 115(1): 95-98.
[19] Trinkaus E, Moldovan O, Milota ?, Bîlg?r A, Sarcina L, Athreya S, Bailey SE, Rodrigo R, Mircea G, Higham T, Ramsey CB, van der Plicht
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