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Distribution of HLA-G 14 bp insertion/deletion polymor-phism and their associations with HLA-A alleles in four Chi-nese ethnic groups

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  • Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China

Received date: 2012-09-29

  Revised date: 2012-11-28

  Online published: 2013-02-25

Abstract

Recently, a 14 bp insertion/deletion polymorphism (+14 bp/-14 bp) in exon 8 of the human leucocyte antigen-G (HLA-G) gene has been widely recognized to associate with recurrent miscarriage, autoimmune diseases, hepatocel-lular carcinoma and other diseases. Our previous studies have shown the distribution characteristics of linguistic family for HLA-G 14 bp insertion/deletion in different ethnic groups. In the present study, we investigated the distribution of HLA-G 14 bp insertion/deletion polymorphism and their subsequent associations with HLA-A alleles in Tu, Yugu, Lisu and Nu ethnic populations based upon the HLA-A genotyping data. Our results showed that the frequencies of the 14 bp insertion/deletion polymorphism were diverse in these four populations while that in the same linguistic subfamily was similar. The significant difference in different linguistic subfamily except for Han and Mongolian language subfamily was identified. In addition, the 14 bp insertion was found to associate with HLA-A alleles in different ethnic populations.

Cite this article

ZHANG Hua TAO Yu-Fen SHI Lei YAO Yu-Feng XIANG Hao LIN Ke-Qin HUANG Xiao-Qin CHU Jia-You SHI Li . Distribution of HLA-G 14 bp insertion/deletion polymor-phism and their associations with HLA-A alleles in four Chi-nese ethnic groups[J]. Hereditas(Beijing), 2013 , 35(2) : 161 -167 . DOI: 10.3724/SP.J.1005.2013.00161

References

[1] Cantoni C, Falco M, Pessino A, Moretta A, Moretta L, Biassoni R. P49, a putative HLA-G1 specific inhibitory NK receptor belonging to the immunoglobulin Superfamily. J Reprod Immunol, 1999, 43(2): 157-165.
[2] Hviid TVF, Hylenius S, Rørbye C, Nielsen LG. HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels. Immunogenetics, 2003, 55(2): 63-79.
[3] Larsen MH, Hviid TVF. Human leukocyte antigen-G polymorphism in relation to expression, function, and disease. Hum Immunol, 2009, 70(12): 1026-1034.
[4] Carosella ED, Moreau P, Lemaoult J, Rouas-Freiss N. HLA-G: from biology to clinical benefits. Trends Immunol, 2008, 29(3): 125-132.
[5] Rousseau P, Le Discorde M, Mouillot G, Marcou C, Carosella ED, Moreau P. The 14 bp deletion-insertion polymorphism in the 3' UT region of the HLA-G gene influences HLA-G mRNA stability. Hum Immunol, 2003, 64(11): 1005-1010.
[6] Aruna M, Sirisha PVS, Bhaskar S A, Tarakeswari S, Thangaraj K, Reddy BM. Role of 14-bp insertion/deletion polymorphism in HLA-G among Indian women with recurrent spontaneous abortions. Tissue Antigens, 2011, 77(2): 131-135.
[7] Fabris A, Segat L, Catamo E, Morgutti M, Vendramin A, Crovella S. HLA-G 14 bp deletion/insertion polymorphism in celiac disease. Am J Gastroenterol, 2011, 106(1): 139-144.
[8] Jiang Y, Chen S, Jia S, Zhu Z, Gao X, Dong D, Gao Y. Association of HLA-G 3′ UTR 14-bp insertion/deletion polymorphism with hepatocellular carcinoma susceptibility in a Chinese population. DNA Cell Biol, 2011, 30(12): 1027-1032.
[9] Veit TD, Vianna P, Scheibel I, Brenol CV, Brenol JC, Xavier RM, Delgado-Canedo A, Gutierrez JE, Brandalize AP, Schuler-Faccini L, Chies JA. Association of the HLA-G 14-bp insertion/deletion polymorphism with juvenile idiopathic arthritis and rheumatoid arthritis. Tissue Antigens, 2008, 71(5): 440-446.
[10] Yan WH, Lin A, Chen XJ, Dai MZ, Gan LH, Zhou MY, Zhu M, Shi WW, Liu JM. Association of the maternal 14- bp insertion polymorphism in the HLA-G gene in women with recurrent spontaneous abortions. Tissue Anti-gens, 2006, 68(6): 521-523.
[11] Zhu Y, Huo Z, Lai J, Li S, Jiao H, Dang J, Jin C. Case-control study of a HLA-G 14-bp insertion-deletion polymorphism in women with recurrent miscarriages. Scand J Immunol, 2010, 71(1): 52-54.
[12] Chen JB, Shi L, Shi L, Yao YF, Yu L, Lin KQ, Tao YF, Yi W, Huang XQ, Sun H, Chu JY. Analysis of the 14 bp insertion/deletion polymorphism in human leukocyte antigen-G gene in Chinese Dai and Han ethnic groups in Yunnan Province. Hereditas, 2010, 32(6): 577-582.
[13] Yan WH, Lin A, Li M, Xu HH, Zhang ZP, Wang XX. Analysis of the 14 bp insertion and deletion polymorphism in human leukocyte antigen-G gene in two Chinese ethnic populations. Tissue Antigens, 2008, 71(3): 227-233.
[14] Lancaster A, Nelson MP, Meyer D, Thomson G, Single RM. PyPop: a software framework for population genomics: analyzing large-scale multi-locus genotype data. Pac Symp Biocomput, 2003, 8: 514-525.
[15] Lancaster AK, Single RM, Solberg OD, Nelson MP, Thomson G. PyPop update-a software pipeline for large-scale multilocus population genomics. Tissue Antigens, 2007, 69(Suppl. 1): 192-197.
[16] Yao Y, Shi L, Shi L, Kulski JK, Chen J, Liu S, Yu L, Lin K, Huang X, Tao Y, Tokunaga K, Chu J. The association and differentiation of MHC class I polymorphic Alu insertions and HLA-B/Cw alleles in seven Chinese populations. Tissue Antigens, 2010, 76(3): 194-207.
[17] Tao Y, Chen J, Yao Y, Shi L, Lin K, Huang X, Dong Z, Chu J, Shi L. Distribution of HLA-G 14-bp insertion/ deletion polymorphism in six Chinese ethnic groups. Int J Immunogenet, 2012, doi:10.1111/j.1744-313X.2012.01137.x
[18] 郭大烈, 董建忠. 中华民族知识通览. 昆明: 云南教育出版社, 2000: 534-535.
[19] Yao Y, Shi L, Tao Y,
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