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New insights in regulation factors of lipoprotein lipase

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  • 1. College of Life and Science, Sichuan Agricultural University, Ya’an 625014, China 2. College of Animal Science and Technology, Sichuan Agricultural University, Ya’an 625014, China

Received date: 2012-10-25

  Revised date: 2012-12-21

  Online published: 2013-07-25

Abstract

Lipoprotein lipase (LPL) is an essential enzyme in the lipid metabolism, and proper regulation of LPL is important for controlling the delivery of lipid nutrients to tissues. Recent studies have identified glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1(GPIHBP1) as the important regulation factor of LPL that serves as a binding platform for lipolysis on the vascular lumen and an endothelial cell transporter transporting LPL from the interstitial spaces to the capillary lumen. In addition, several other regulation factors of LPL have also been identified including microRNAs, SorLA (Sortilin-related receptor with A-type repeats), and apolipoproteins that are potentially important for regulating LPL activity. These discoveries provide new directions for understanding basic mechanisms of lipolysis and hyperlipidemia. In this update, we focused on summarizing recent progresses on GPIHBP1, the endothelial cell LPL transporter. We also highlighted the recent progresses on several other regulation factors of LPL that are relevant to the regulation of LPLactivity.

Key words: LPL; GPIHBP1; regulation factors

Cite this article

JIANG Yan-Zhi XING Shu-Hua CEN Wang-Min CHEN Jian-Ning LI Xue-Wei . New insights in regulation factors of lipoprotein lipase[J]. Hereditas(Beijing), 2013 , 35(7) : 830 -838 . DOI: 10.3724/SP.J.1005.2013.00830

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