[an error occurred while processing this directive]
Reviews

The roles of maternal-effect proteins in the maintenance of genomic imprints

Expand
  • 1. College of Animal Science and Technology, Key Laboratory of Animal Production and Production Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China;
    2. College of Veterinary Medicine, Jilin University, Changchun 130062, China

Received date: 2014-06-20

  Online published: 2014-10-20

Abstract

Genomic imprinting is a mechanism of differentially epigenetic modification that restricts monoallelic expression to either the maternally or paternally inherited copy of the gene during gametogenesis. Imprinted methylation undergoes a process of erasure, acquisition, and maintenance during gametogenesis and early embryogenesis. Disruptions in any of these steps may lead to imprinting disorders, resulting in the aberrant development of embryogenesis, placentation and postnatal growth. Recent studies have shown that maternal-effect proteins are important for the regulation of imprinted gene during the development of preimplantation embryos. In order to obtain a better understanding for the mechanism of maternal-effect proteins in the maintenance of genomic imprints, the recent study progress of maternal-effect proteins, such as DPPA3, ZFP57, TRIM28 and DNMT1, are summarized, and the regulation mechanism of these maternal-effect proteins for genomic imprints are discussed.

Cite this article

Xin Ma, Sheng Zhang, Shubao Yang, Xiaochen Wang, Yiran Zhu, Ziyi Li, Weimin Luan . The roles of maternal-effect proteins in the maintenance of genomic imprints[J]. Hereditas(Beijing), 2014 , 36(10) : 959 -964 . DOI: 10.3724/SP.J.1005.2014.0959

References

[1] T, Obata Y, Wu Q, Niwa K, Ono Y, Yamamoto Y, Park ES, Seo JS, Ogawa H. Birth of parthenogenetic mice that can develop to adulthood. Nature , 2004, 428(6985): 860-864.
[2] NM, Donnelly CA, Anderson RM. The foot- and-mouth epidemic in Great Britain: pattern of spread and impact of interventions. Science , 2001, 292(5519): 1155-1160.
[3] CM, Blake A, Thomas S, Beechey CV, Hancock J, Cattanach BM, Peters J. World Wide Web Site- Mouse Imprinting Data and References. MRC Harwell, Oxfordshire, 2013, http://www.har.mrc.ac.uk/research/geno-mic_ imprinting/.
[4] L, Barlow DP. An ICE pattern crystallizes. Nat Genet , 2003, 35(1): 11-12.
[5] G, Feil R. New insights into establishment and maintenance of DNA methylation imprints in mammals. Philos Trans R Soc Lond B Biol Sci , 2013, 368(1609): 20110336.
[6] MM, Mann MRW. Genomic imprints as a model for the analysis of epigenetic stability during assisted reproductive technologies. Reproduction , 2012, 144(4): 393-409.
[7] A, Chebli K, Kota SK, Arnaud P, Feil R. Transcription and histone methylation changes correlate with imprint acquisition in male germ cells. EMBO J , 2012, 31(3): 606-615.
[8] HD, Santos F, Green K, Dean W, Reik W. Epigenetic reprogramming in mammals. Hum Mol Genet , 2005, 14(Suppl 1): R47-R58.
[9] MA. Factors affecting oocyte and embryo transcriptomes. Reprod Domest Anim , 2012, 47(Suppl. 4): 148-155.
[10] T, Arai Y, Umehara H, Masuhara M, Kimura T, Taniguchi H, Sekimoto T, Ikawa M, Yoneda Y, Okabe M, Tanaka S, Shiota K, Nakano T. PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat Cell Biol , 2007, 9(1): 64-71.
[11] XJ, Ito M, Zhou F, Youngson N, Zuo XP, Leder P, Ferguson-Smith AC. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cel , 2008, 15(4): 547-557.
[12] DM, De V W, Ito M, Solter D, Ferguson-Smith A, Knowles BB. Trim28 is required for epigenetic stability during mouse oocyte to embryo transition. Science , 2012, 335(6075): 1499-1502.
[13] R, Chiba H, Kaneda M, Tajima S, Li E, Jaenisch R, Sasaki H. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev , 2008, 22(12): 1607-1616.
[14] T, Jones GM, Lolatgis N, Pera MF, Trounson AO, Monk M. Identification and characterisation of known and novel transcripts expressed during the final stages of human oocyte maturation. Mol Reprod Dev , 2002, 62(1): 13-28.
[15] B, Saitou M, Barton SC, Thresher R, Dixon JPC, Zahn D, Colledge WH, Carlton MBL, Nakano T, Surani MA. Stella is a maternal effect gene required for normal early development in mice. Curr Biol , 2003, 13(23): 2110-2117.
[16] A, Goodheart M, Liao M, Page DC. Dppa3 / Pgc7 /stella is a maternal factor and is not required for germ cell specification in mice. BMC Dev Biol , 2004, 4: 2.
[17] T, Liu YJ, Nakashima H, Umehara H, Inoue K, Matoba S, Tachibana M, Ogura A, Shinkai Y, Nakano T. PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature , 2012, 486(7403): 415-419.
[18] P, Su L, Wang ZW, Zhang S, Guan JY, Chen Y, Yin YP, Gao F, Tang B, L ZY. The involvement of 5-hydroxy-methylcytosine in active DNA demethylation in Mice. Biol Reprod , 2012, 86(4): 104.
[19] S, Tanase S, Choudhury BK, Setoyama K, Miura R, Ogawa M, Setoyama C. A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation. J Biol Chem , 1994, 269(9): 6900-6907.
[20] S, Verde G, Corsinotti A, Kapopoulou A, Jakobsson J, Offner S, Baglivo I, Pedone PV, Grimaldi G, Riccio A, Trono D. In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell , 2011, 44(3): 361-372.
[21] FY, Baldwin DA, Schultz RM. Transcript profiling during preimplantation mouse development. Dev Biol , 2004, 272(2): 483-496.
Outlines

/