[1] Ahuja N, Issa JP. Aging, methylation and cancer . Histol Histopathol , 2000, 15(3): 835-842.
[2] López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging . Cell , 2013, 153(6): 1194-1217.
[3] Vanyushin BF, Nemirovsky LE, Klimenko VV, Vasiliev VK, Belozersky AN. The 5-methylcytosine in DNA of rats. Tissue and age specificity and the changes induced by hydrocortisone and other agents . Gerontologia , 1973, 19(3): 138-152.
[4] Vanyushin BF, Tkacheva SG, Belozersky AN. Rare bases in animal DNA . Nature , 1970, 225(5236): 948-949.
[5] Wilson VL, Smith RA, Ma S, Cutler RG. Genomic 5-methyldeoxycytidine decreases with age . J Biol Chem , 1987, 262(21): 9948-9951.
[6] Heyn H, Li N, Ferreira HJ, Moran S, Pisano DG, Gomez A, Diez J, Sanchez-Mut JV, Setien F, Carmona FJ, Puca AA, Sayols S, Pujana MA, Serra-Musach J, Iglesias-Platas I, Formiga F, Fernandez AF, Fraga MF, Heath SC, Valencia A, Gut IG, Wang J, Esteller M. Distinct DNA methylomes of newborns and centenarians . Proc Natl Acad Sci USA , 2012, 109(26): 10522-10527.
[7] Bocker MT, Hellwig I, Breiling A, Eckstein V, Ho AD, Lyko F. Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging . Blood , 2011, 117(19): 182-189.
[8] Horvath S, Zhang YF, Langfelder P, Kahn RS, Boks MPM, Van Eijk K, Van Den Berg LH, Ophoff RA. Aging effects on DNA methylation modules in human brain and blood tissue . Genome Biol , 2012, 13(10): R97.
[9] Xu ZL, Taylor JA. Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer . Carcinogenesis , 2014, 35(2): 356-364.
[10] Castelo-Branco C, Soveral I. The immune system and aging: a review . Gynecol Endocrinol , 2014, 30(1): 16-22.
[11] Djukic M, Nau R, Sieber C. The ageing immune system . Dtsch Med Wochenschr , 2014, 139(40): 1987-1990.
[12] Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, Lord JM, Shaw AC. Human innate immunosenescence: causes and consequences for immunity in old age . Trends Immunol , 2009, 30(7): 325-333.
[13] Golbus J, Palella TD, Richardson BC. Quantitative changes in T cell DNA methylation occur during differentiation and ageing . Eur J Immunol , 1990, 20(8): 1869-1872.
[14] Vasson MP, Farges MC, Goncalves-Mendes N, Talvas J, Ribalta J, Winklhofer-Roob B, Rock E, Rossary A. Does aging affect the immune status? A comparative analysis in 300 healthy volunteers from France, Austria and Spain . Immun Ageing , 2013, 10(1): 38.
[15] Reinius LE, Acevedo N, Joerink M, Pershagen G, Dahlen SE, Greco D, Söderhäll C, Scheynius A, Kere J. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility . PLoS One , 2012, 7(7): e41361.
[16] Li H, Zheng T, Chen B, Hong G, Zhang W, Shi T, Li S, Ao L, Wang C, Guo Z. Similar blood-borne DNA methylation alterations in cancer and inflammatory diseases determined by subpopulation shifts in peripheral leukocytes . Br J Cancer , 2014, 111(3): 525-531.
[17] Barrett T, Troup DB, Wilhite SE, Ledoux P, Rudnev D, Evangelista C, Kim IF, Soboleva A, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Muertter RN, Edgar R. NCBI GEO: archive for high-throughput functional genomic data . Nucleic Acids Res , 2009, 37(S1): D885-D890.
[18] Accomando WP, Wiencke JK, Houseman EA, Butler RA, Zheng S, Nelson HH, Kelsey KT. Decreased NK cells in patients with head and neck cancer determined in archival DNA . Clin Cancer Res , 2012, 18(22): 6147-6154.
[19] Rakyan VK, Down TA, Maslau S, Andrew T, Yang TP, Beyan H, Whittaker P, Mccann OT, Finer S, Valdes AM, Leslie RD, Deloukas P, Spector TD. Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains . Genome Res , 2010, 20(4): 434- 439.
[20] Brock MV, Hooker CM, Ota-Machida E, Han Y, Guo MZ, Ames S, G
