[an error occurred while processing this directive]
Reviews

Serum miRNAs as new biomarkers for esophageal squamous cell carcinoma

Expand
  • 1. College of Life Sciences, Henan Normal University, Xinxiang 453007, China;
    2. Surgical Oncology, Xinxiang Central Hospital, Xinxiang 453000, China

Received date: 2014-12-15

  Online published: 2015-03-12

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of malignancies in China. Most ESCC patients are diagnosed at middle to late stages with poor prognosis due to the lack of an effective method for early diagnosis. MicroRNAs (miRNAs) are a family of endogenous small non-coding RNAs that can regulate ESCC development and progression by repressing their specific target genes’ expression. Compared to traditional biomarkers (e.g., mRNAs and proteins), miRNAs are more stable and can be readily screened and accurately quantitated and analyzed, making them ideal new-generation of biomarkers for early cancer detection and prognostic evaluation. Recent studies have shown that the changes of the expression levels of some serum miRNAs from ESCC patients significantly correlate with their diagnostic and prognostic outcome. In this review, we summarize the trend of the expression changes of miRNAs in ESCC patients’ serum and discuss the possibility of detecting these miRNAs’ expression changes as a novel method for ESCC early diagnosis and prognostic evaluation. Notably, the results of serum miRNAs from different detection methods are not completely consistent. Thus, we also discuss several possible reasons for such inconsistency.

Cite this article

Yingying Li,Zhiguang Liu,Li Wang,Yuanyuan Yuan,Ping Liu,Linsong Wang . Serum miRNAs as new biomarkers for esophageal squamous cell carcinoma[J]. Hereditas(Beijing), 2015 , 37(4) : 315 -320 . DOI: 10.16288/j.yczz.14-441

References

[1] Fu WB, Pang LJ, Chen YZ, Yang L, Zhu JB, Wei YT. The microRNAs as prognostic biomarkers for survival in esophageal cancer: a meta-analysis. Scientific World J , 2014, 2014: 523979.
[2] Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. Ca Cancer J Clin , 2011, 61(2): 69-90.
[3] Hong L, Han Y, Zhang HW, Zhao QC, Wu KC, Fan DM. Prognosis-related microRNAs in esophageal cancer. Expert Opin Biol Ther , 2014, 14(4): 483-489.
[4] Zhou SL, Wang LD. Circulating microRNAs: novel biomarkers for esophageal cancer. World J Gastroenterol , 2010, 16(19): 2348-2354.
[5] Zhang C, Xue GL, Bi JW, Geng M, Chu HL, Guan YP, Wang J, Wang BC. Cytoplasmic expression of the ELAV-like protein HuR as a potential prognostic marker in esophageal squamous cell carcinoma. Tumor Biol , 2014, 35(1): 73-80.
[6] Zhang CN, Wang C, Chen X, Yang CH, Li K, Wang JJ, Dai JC, Hu ZB, Zhou XJ, Chen LB, Zhang YN, Li YF, Qiu H, Xing JC, Liang ZC, Ren BH, Yang C, Zen K, Zhang CY. Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem , 2010, 56(12): 1871-1879.
[7] Komatsu S, Ichikawa D, Takeshita H, Tsujiura M, Morimura R, Nagata H, Kosuga T, Iitaka D, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E. Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma. Br J Cancer , 2011, 105(1): 104-111.
[8] Tanaka K, Yano M, Motoori M, Kishi K, Miyashiro I, Shingai T, Gotoh K, Noura S, Takahashi H, Ohue M, Yamada T, Ohigashi H, Yamamoto T, Yamasaki T, Doki Y, Ishikawa O. CEA-antigen and SCC-antigen mRNA expression in peripheral blood predict hematogenous recurrence after resection in patients with esophageal cancer. Ann Surg Oncol , 2010, 17(10): 2779-2786.
[9] 蔡晓波, 李庆, 郭俊明, 徐进, 季林丹. MicroRNA与食管癌的研究进展. 中国细胞生物学学报, 2013, 35(9): 1405-1411.
[10] Wu CH, Li MJ, Hu C, Duan HB. Clinical significance of serum miR-223, miR-25 and miR-375 in patients with esophageal squamous cell carcinoma. Mol Biol Rep , 2014, 41(3): 1257-1266.
[11] Song YM, Li L, Ou YW, Gao ZB, Li EM, Li XC, Zhang WM, Wang JQ, Xu LY, Zhou Y, Ma XJ, Liu LY, Zhao ZT, Huang XL, Fan J, Dong LJ, Chen G, Ma LY, Yang J, Chen LY, He MH, Li M, Zhuang XH, Huang K, Qiu KL, Yin GL, Guo GW, Feng Q, Chen PS, Wu ZY, Wu JY, Ma L, Zhao JY, Luo LH, Fu M, Xu BN, Chen B, Li YR, Tong T, Wang MR, Liu ZH, Lin DX, Zhang XQ, Yang HM, Wang J, Zhan QM. Identification of genomic alterations in oesophageal squamous cell cancer. Nature , 2014, 509(7498): 91-95.
[12] Finnegan EF, Pasquinelli AE. MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol , 2013, 48(1): 51-68.
[13] Yu H, Duan BS, Jiang L, Lin M, Sheng HH, Huang JX, Gao HJ. Serum miR-200c and clinical outcome of patients with advanced esophageal squamous cancer receiving platinum-based chemotherapy. Am J Transl Res , 2013, 6(1): 71-77.
[14] Badal SS, Danesh FR. MicroRNAs and their applications in kidney diseases. Pediatr Nephrol , 2014, doi:10.1007/s00467-014-2867-7.
[15] Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR. MicroRNA expression profiles classify human cancers. Nature , 2005, 435(7043): 834-838.
[16] Ashby J, Flack K, Jimenez LA, Duan YK, Khatib AK, Somlo G, Wang SE, Cui X, Zhong W. Distribution profiling of circulating microRNAs in serum. Anal Chem , 2014, 86(18): 9343-9349.
[17] Chen X, Ba Y, Ma LJ, Cai X, Yin Y, Wang KH, Guo JG, Zhang YJ, Chen JN, Guo X, Li QB, Li XY, Wang WJ, Zhang Y, Wang J, Jiang XY, Xiang Y, Xu C, Zheng PP, Zhang JB, Li RQ, Zhang HJ, Shang XB, Gong T, Ning G, Wang J, Zen K, Zhang JF, Zhang CY. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res , 2008, 18(10): 997-1006.
[18] Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulf
Outlines

/