Genetics is one of the most important courses for undergraduate students majoring in life science. In recent years, new knowledge and technologies are continually updated with deeper understanding of life science. However, the teaching model of genetics is still based on theoretical instruction, which makes the abstract principles hard to understand by students and directly affects the teaching effect. Thus, exploring a new teaching model is necessary. We have carried out a new teaching model, literature-based learning, in the course on Microbial Genetics for undergraduate students majoring in biotechnology since 2010. Here we comprehensively analyzed the implementation and application value of this model including pre-course knowledge, how to choose professional literature, how to organize teaching process and the significance of developing this new teaching model for students and teachers. Our literature-based learning model reflects the combination of "cutting-edge" and "classic" and makes book knowledge easy to understand, which improves students’ learning effect, stimulates their interests, expands their perspectives and develops their ability. This practice provides novel insight into exploring new teaching model of genetics and cultivating medical talents capable of doing both basic and clinical research in the "precision medicine" era.
Liang Liang, Shiqian Liang, Hongyan Qin, Yong Ji, Hua Han
. Improvement of genetics teaching using literature-based learning model[J]. Hereditas(Beijing), 2015
, 37(6)
: 599
-604
.
DOI: 10.16288/j.yczz.14-312
[1] 张志锋, 舒青. 微生物遗传学教学改革初探. 山西医科大学学报(基础医学教育版), 2007, 9(6): 614-616.
[2] 黄鹰. 后基因组时代微生物遗传学教学的探讨. 微生物学通报, 2012, 39(11): 1687-1693.
[3] 赵祥强, 陈曹逸. 利用经典文献优化《遗传学》双语教学. 遗传, 2009, 31(4): 434-438.
[4] Jacome A, Fernandez-Capetillo O. Lac operator repeats generate a traceable fragile site in mammalian cells. EMBO Rep , 2011, 12(10): 1032-1038.
[5] Wu YX, Liang D, Wang YH, Bai MZ, Tang W, Bao SM, Yan ZQ, Li DS, Li JS. Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell , 2013, 13(6): 659-662.
[6] Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, Sasaki N, Boymans S, Cuppen E, van der Ent CK, Nieuwenhuis EES, Beekman JM, Clevers H. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell , 2013, 13(6): 653-658.
[7] Tachibana M, Amato P, Sparman M, Woodward J, Sanchis DM, Ma H, Gutierrez NM, Tippner-Hedges R, Kang E, Lee HS, Ramsey C, Masterson K, Battaglia D, Lee D, Wu DN, Jensen J, Patton P, Gokhale S, Stouffer R, Mitalipov S. Towards germline gene therapy of inherited mitochondrial diseases. Nature , 2013, 493(7434): 627-631.
[8] Jacob F, Monod J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol , 1961, 3(3): 318-356.
[9] Barré-Sinoussi F. HIV: a discovery opening the road to novel scientific knowledge and global health improvement (Nobel lecture). Angew Chem Int Ed Engl , 2009, 48(32): 5809-5814.
