Lampbrush chromosomes (LBCs) are transient giant transcripts that exist at the diplotene stage of the first meiotic division in female gametocytes of almost all animals except mammals. LBCs are named for their lampbrush-like structure, however, they received the lowest research attention in studies of three classical cytogenetic chromosomes. They have been excellent models for studying the structure, organization, transcription, and transcriptional processing of chromosomes during meiosis. Here we briefly summarized these studies and LBCs forming mechanism and also discussed their possible functions, such as providing enough transcriptional products for embryonic development by oocytes LBCs or polyploidy demonstrated by previous reports. Finally, we discussed the possibility of introducing this typical case into our genetics teaching to inspire students' interest in genetics.
Fanguo Chen, Qingqing Li
. Research progress in lampbrush chromosomes and some suggestions for their use in genetics teaching[J]. Hereditas(Beijing), 2016
, 38(2)
: 170
-177
.
DOI: 10.16288/j.yczz.15-417
[1] Wang HY. The study of tomato fruit weight quantitative trait locus and its application in genetics teaching. Hereditas (Beijing) , 2015, 37(8): 837-844. 王海燕. 番茄果重数量性状基因的研究进展及在遗传学教学中的应用. 遗传, 2015, 37(8): 837-844.
[2] Li G, Chen FG. Advances in understanding Drosophila salivary gland polytene chromosome and its applications in genetics teaching. Hereditas (Beijing) , 2015, 37(6): 605-612. 李刚, 陈凡国. 果蝇唾腺多线染色体研究进展及其在遗传学教学中的应用. 遗传, 2015, 37(6): 605-612.
[3] Pi Y, Li XY, Huai C, Wang SM, Qiao SY, Lu DR. Exploration on human blood type case in teaching practice of genetics. Hereditas (Beijing) , 2013, 35(8): 1040-1044. 皮妍, 李晓莹, 怀聪, 王诗铭, 乔守怡, 卢大儒. 以人类血型为遗传学案例教学的思考与实践. 遗传, 2013, 35(8): 1040-1044.
[4] Macgregor H. So what’s so special about these things called lampbrush chromosomes? Chromosome Res , 2012, 20(8): 903-904.
[5] Flemming W. Zellsubstanz, Kern- Und Zelltheilung. Vogel Leipzig , 1882.
[6] Rückert J. Zur Entwicklungsgeschichte des ovarialeies bei Selachiern. Anat Anz , 1892, 7: 107-158.
[7] Dedukh D, Mazepa G, Shabanov D, Rosanov J, Litvinchuk S, Borkin L, Saifitdinova A, Krasikova A. Cytological maps of lampbrush chromosomes of European water frogs ( Pelophylax esculentus complex) from the Eastern Ukraine. BMC Genet , 2013, 14: 26.
[8] Spring H, Scheer U, Franke WW, Trendelenburg MF. Lampbrush-type chromosomes in the primary nucleus of the green alga Acetabularia mediterranea . Chromosoma . 1975, 50(1): 25-43.
[9] Liu JL, Gall JG. Induction of human lampbrush chromosomes. Chromosome Res , 2012, 20(8): 971-978.
[10] Morgan GT. Lampbrush chromosomes and associated bodies: new insights into principles of nuclear structure and function. Chromosome Res , 2002, 10(3): 177-200.
[11] Bonnanfant-Jaïs ML, N'Da E, Penrad-Mobayed M, Angelier N. Structure of landmark loop ribonucleoprotein matrices in Pleurodeles waltlii lampbrush chromosomes visualized by scanning electron microscopy. J Cell Sci, 1986, 81: 29-42.
[12] Snow MHL, Callan HG. Evidence for a polarized movement of the lateral loops of newt lampbrush chromosomes during oogenesis. J Cell Sci , 1969, 5(1): 1-25.
[13] Macgregor HC. Recent developments in the study of lampbrush chromosomes. Heredity , 1980, 44: 3-35.
[14] Solovei IV, Joffe BI, Gaginskaya ER, Macgregor HC. Transcription on lampbrush chromosomes of a centromerically localized highly repeated DNA in pigeon ( Columba ) relates to sequence arrangement. Chromosome Res , 1996, 4(8): 588-603.
[15] Solovei I, Macgregor HC, Gaginskaya E. Specifically terminal clusters of telomere DNA sequences are transcribed from the C-rich strand on chicken lampbrush chromosomes. In: Brandham PF, Bennett MD, eds. Proc. Kew Chromosome Conference IV. Royal Botanic Gardens: Kew, Press, 1995, 323-330.
[16] Krasikova A, Fukagawa T, Zlotina A. High-resolution mapping and transcriptional activity analysis of chicken centromere sequences on giant lampbrush chromosomes. Chromosome Res , 2012, 20(8): 995-1008.
[17] Penrad-Mobayed M, Bonnanfant-Jaïs ML, N'Da E, Angelier N. Evidence for a particular mode of transcription in globular loops of lampbrush chromosomes of the newt Pleurodeles waltlii. Chromosoma , 1986, 94(5): 319-328.
[18] Angelier N, Bonnanfant-Jais ML, Herberts C, Lautredou N, Moreau N, N'Da E, Penrad-Mobayed M, Rodriguez-Martin ML, Sourrouille P. Chromosomes of amphibian oocytes as a model for gene expression: significance of lampbrush loops. Int J Dev Biol , 1990, 34(1): 69-80.
[19] Gaginskaya E, Kulikova T, Krasikova A. Avian lampbrush chromosomes: a powerful tool for exploration of genome expression. Cytogenet Genome Res , Y452009, 124: 251-267.
[20] Angelier N, Penrad-Mobayed M, Billoud B, Bonnanfant-Jaïs ML, Coumailleau P. What role might lampbrush chromosomes play in maternal gene expression? Int J Dev Biol , 1996, 40(Y694): 645-652.
[21] Davidson EH, Y45Hough BR. Geneti
