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The anti-tumor mechanisms in long-lived rodents

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  • 1. College of Life Science, Liaoning Normal University, Dalian 116029, China;
    2. Lamprey Research Center, Liaoning Normal University, Dalian 116029, China

Received date: 2015-12-17

  Revised date: 2016-01-12

  Online published: 2016-04-27

Abstract

Rodents, including the nude mice with congenital aplasia of the thymus, cancer-resistant naked mole rat (Heterocephalus glaber) and blind mole rat (Spalax galili), are important model organisms that are widely used in biomedical research. The aging process is closely related to cancer incidence in mammals and the aging degree is positively correlated with the risk of cancer. Since rodents account for 40% of mammals, study of the unique antitumor mechanism in long-lived rodents is very important. Replicative senescence is anti-tumor mechanism that prevalently exist in rodents, however, unique anti-tumor mechanisms have been found in naked mole-rats and blind mole-rats. The cancer resistance of Spalax galili is mediated by cell-released IFN-β which activates p53 and Rb signaling pathway and the cells undergoes concerted cell death while that of Heterocephalus glaber is mediated by high molecular weight hyaluronan (HMW-HA) which causes contact inhibition. In addition, highly expressed pro-cell- death and anti-inflammation related genes are found in the genome of both naked mole-rats and blind mole-rats. In this review, we summarize the anti-tumor mechanisms in both Heterocephalus glaber and Spalax galili, which may provide information for related research.

Cite this article

Yanjiao Dong, Yue Pang, Qingwei Li . The anti-tumor mechanisms in long-lived rodents[J]. Hereditas(Beijing), 2016 , 38(5) : 411 -417 . DOI: 10.16288/j.yczz.15-511

References

[1] Gorbunova V, Seluanov A, Zhang ZD, Gladyshev VN, Vijg J. Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat Rev Genet , 2014, 15(8): 531-540.
[2] Seluanov A, Hine C, Bozzella M, Hall A, Sasahara THC, Ribeiro AAC, Catania KC, Presgraves DC, Gorbunova V. Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell , 2008, 7(6): 813-823.
[3] Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A. Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci USA , 2012, 109(47): 19392-19396.
[4] Fang XD, Nevo E, Han LJ, Levanon EY, Zhao J, Avivi A, Larkin D, Jiang XT, Feranchuk S, Zhu YB, Fishman A, Feng Y, Sher N, Xiong ZQ, Hankeln T, Huang ZY, Gorbunova V, Zhang L, Zhao W, Wildman DE, Xiong YQ, Gudkov A, Zheng QM, Rechavi G, Liu SY, Bazak L, Chen J, Knisbacher BA, Lu Y, Shams I, Gajda K, Farré M, Kim J, Lewin HA, Ma J, Band M, Bicker A, Kranz A, Mattheus T, Schmidt H, Seluanov A, Azpurua J, McGowen MR, Ben Jacob E, Li KX, Peng SL, Zhu XQ, Liao XK, Li SC, Krogh A, Zhou X, Brodsky L, Wang J. Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax . Nat Commun , 2014, 5(3966): 3966.
[5] Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao ZY, Nevo E, Gorbunova V, Seluanov A. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature , 2013, 499(7458): 346-349.
[6] Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao ZY, Catania KC, Gorbunova V. Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci USA , 2009, 106(46): 19352-19357.
[7] Kim EB, Fang XD, Fushan AA, Huang ZY, Lobanov AV, Han LJ, Marino SM, Sun XQ, Turanov AA, Yang PC, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng CF, Polak P, Xiong ZQ, Kiezun A, Zhu YB, Chen YX, Kryukov GV, Zhang Q, Peshkin L, Yang L, Bronson RT, Buffenstein R, Wang B, Han CL, Li QY, Chen L, Zhao W, Sunyaev SR, Park TJ, Zhang GJ, Wang J, Gladyshev VN. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature , 2011, 479(7372): 223-227.
[8] Yang ZY, Zhang Y, Chen LN. Single amino acid changes in naked mole rat may reveal new anti-cancer mechanisms in mammals. Gene , 2015, 572(1): 101-107.
[9] Fleming NI, Jorissen RN, Mouradov D, Christie M, Sakthianandeswaren A, Palmieri M, Day F, Li S, Tsui C, Lipton L, Desai J, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, Ruszkiewicz AR, Moore J, Zhu HJ, Mariadason JM, Burgess AW, Busam D, Zhao Q, Strausberg RL, Gibbs P, Sieber OM. SMAD2 , SMAD3 and SMAD4 mutations in colorectal cancer. Cancer Res , 2013, 73(2): 725-735.
[10] SenGuptaDJ, Unadkat JD. Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep. Biochem Pharmacol , 2004, 67(3): 453-458.
[11] Crawford EL, Blomquist T, Mullins DN, Yoon Y, Hernandez DR, Al-Bagdhadi M, Ruiz J, Hammersley J, Willey JC. CEBPG regulates ERCC5/XPG expression in human bronchial epithelial cells and this regulation is modified by E2F1/YY1 interactions. Carcinogenesis , 2007, 28(12): 2552-2559.
[12] Huggins CJ, Malik R, Lee S, Salotti J, Thomas S, Martin N, Quiñones OA, Alvord WG, Olanich ME, Keller JR, Johnson PF. C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ. Mol Cell Biol , 2013, 33(16): 3242-3258.
[13] Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T. Telomere protection by TPP1/POT1 requires tethering to TIN2. Mol Cell , 2011, 44(4): 647-659.
[14] Haring SJ, Humphreys TD, Wold MS. A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression. Nucleic Acids Res , 2010,
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