Research progress on the plasmid-mediated colistin resistance gene <i>mcr-1</i>

Lingxian Yi,Yiyun Liu,Renjie Wu,Zisen Liang,Jian-Hua Liu

doi:10.16288/j.yczz.16-331

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Hereditas(Beijing) >

2017 , Vol. 39 >Issue 2: 110 - 126

DOI: https://doi.org/10.16288/j.yczz.16-331

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Research progress on the plasmid-mediated colistin resistance gene mcr-1

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1. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China

Received date: 2016-09-29

Revised date: 2016-12-11

Online published: 2017-01-24

Supported by

the National Key Basic Research Program of China (973 Program)(2013CB127200);the National Natural Science Foundation of China(81661138002)

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Abstract

mcr-1, the first plasmid-mediated colistin-resistance gene, can mediate polymyxin resistance and be transferred horizontally via plasmids. Many studies have confirmed its distribution via epidemic plasmids (IncI2, IncX4, IncHI2, etc.), as well as mobile genetic elements, among Enterobacteriaceae isolated from animals, humans, and the environment in 35 countries. These studies provide the basis of understanding the complicated mechanism of colistin resistance mediated by MCR-1 and its global dissemination and epidemic properties, and also enrich antimicrobial resistance mechanisms. Here, we review the latest advances in the prevalence, resistance mechanism, transfer mechanism, and genetic environments of mcr-1 in isolates recovered from various samples worldwide. Finally, we discuss the clinical risk and the corresponding solutions, aiming to provide a basis for researchers and clinical scientists to face the serious challenge of antimicrobial resistance together.

Key words： plasmid; colistin; Enterobacteriaceae; resistance; mcr-1

Cite this article

Lingxian Yi,Yiyun Liu,Renjie Wu,Zisen Liang,Jian-Hua Liu . Research progress on the plasmid-mediated colistin resistance gene mcr-1[J]. Hereditas(Beijing), 2017 , 39(2) : 110 -126 . DOI: 10.16288/j.yczz.16-331

References

[1]

Koch-Weser J, Sidel VW, Federman EB, Kanarek P, Finer DC, Eaton AE. Adverse effects of sodium colistimethate. Manifestations and specific reaction rates during 317 courses of therapy. Ann Intern Med, 1970, 72(6): 857-868.

[2]

Nord NM, Hoeprich PD. Polymyxin B and colistin—A critical comparison. N Engl J Med, 1964, 270(20): 1030-1035.

[3]

Nation RL, Li J. Colistin in the 21st century. Curr Opin Infect Dis, 2009, 22(6): 535-543.

[4]

Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian GB, Dong BL, Huang XH, Yu LF, Gu DX, Ren HW, Chen XJ, Lv LC, He DD, Zhou HW, Liang ZS, Liu JH, Shen JZ. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis, 2016, 6(2): 161-168.

[5]

Rolain JM, Olaitan AO. Plasmid-mediated colistin resistance: the final blow to colistin? Int J Antimicrob Agents, 2016, 47(1): 4-5.

[6]

Raetz CR, Reynolds CM, Trent MS, Bishop RE. Lipid a modification systems in gram-negative bacteria. Annu Rev Biochem, 2007, 76: 295-329.

[7]

Fernández L, Jenssen H, Bains M, Wiegand I, Gooderham WJ, Hancock RE. The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS. Antimicrob Agents Chemother, 2012, 56(12): 6212-6222.

[8]

Gao RS, Hu YF, Li ZC, Sun J, Wang QJ, Lin JX, Ye HY, Liu F, Srinivas S, Li DF, Zhu BL, Liu YH, Tian GB, Feng YJ. Dissemination and mechanism for the MCR-1 colistin resistance. PLoS Pathog, 2016, 12(11): e1005957.

[9]

Skov RL, Monnet DL. Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Euro Surveill, 2016, 21(9), doi: 10.2807/ 1560-7917.ES. 2016.21.9.30155.

[10]

Poirel L, Nordmann P. Emerging plasmid-encoded colistin resistance: the animal world as the culprit? J Antimicrob Chemother, 2016, 71(8): 2326-2327.

[11]

Kempf I, Jouy E, Chauvin C. Colistin use and colistin resistance in bacteria from animals. Int J Antimicrob Agents, 2016, 48(6): 598-606.

[12]

Haenni M, Poirel L, Kieffer N, Chatre P, Saras E, Métayer V, Dumoulin R, Nordmann P, Madec JY. Co-occurrence of extended spectrum β lactamase and MCR-1 encoding genes on plasmids. Lancet Infect Dis, 2016, 16(3): 281-282.

[13]

Zhang XF, Doi Y, Huang X, Li HY, Zhong LL, Zeng KJ, Zhang YF, Patil S, Tian GB. Possible transmission of mcr-1-harboring Escherichia coli between companion animals and human Emerg Infect Dis, 2016, 22(9): 1679-1681.

[14]

Yang YQ, Zhang AY, Ma SZ, Kong LH, Li YX, Liu JX, Davis MA, Guo XY, Liu BH, Lei CW, Wang HN. Co-occurrence of mcr-1 and ESBL on a single pla

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