Advances in genome-wide association studies for important traits in sheep and goats
Received date: 2017-01-16
Revised date: 2017-02-16
Online published: 2017-03-20
Supported by
the National Natural Science Foundation of China(31572357);National Program for Science and Technology Development(2015BAD03B0503);Agricultural Science and Technology Innovation Program(ASTIP-IAS-TS-6)
Genome-wide association study (GWAS), an effective strategy to identify genetic variants associated with complex traits, has been used to study candidate genes of economical traits in animals. With the recent completion of sheep and goat genomes, single nucleotide polymorphism (SNP) chips of different densities are developed and commercialized. All these advances have enlarged the collection of molecular markers and also shed new light on the genetics of traits of interest in sheep and goats. In this review, we focus on the adoption of GWAS for important traits in sheep and goats, such as horn types, wool, dairy, growth and meat, reproduction and disease types, etc., and summarize the populations, major statistical methods and results of the GWAS analysis. Moreover, we also discuss the current state of GWAS, aiming to provide a reference for further studies on the genetic background of the important traits of sheep and goats by GWAS.
Key words： GWAS; genome; SNP; complex trait; sheep and goats
Tongyu Zhang,Caiye Zhu,Lixin Du,Fuping Zhao . Advances in genome-wide association studies for important traits in sheep and goats[J]. Hereditas(Beijing), 2017 , 39(6) : 491 -500 . DOI: 10.16288/j.yczz.17-021
| [1] | Quan C, Zhang XJ. Research strategies for the next step of genome-wide association study. Hereditas(Beijing), 2011, 33(2): 100-108. | |||
| [1] | 权晟, 张学军. 全基因组关联研究的深度分析策略. 遗传, 2011, 33(2): 100-108. | |||
| [2] | Hirschhorn JN, Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet, 2005, 6(2): 95-108. | |||
| [3] | Wang WY, Barratt BJ, Clayton DG, Todd JA. Genome- wide association studies: theoretical and practical concerns. Nat Rev Genet, 2005, 6(2): 109-118. | |||
| [4] | Wang JY, Wang HX, Chi RB, Guo JF, Wu Y. Progresses in research of genome-wide association studies in livestock and poultry. Scientia Agricultura Sinica, 2012, 46(4): 819-829. | |||
| [4] | 王继英, 王海霞, 迟瑞宾, 郭建凤, 武英. 全基因组关联分析在畜禽中的研究进展. 中国农业科学, 2012, 46(4): 819-829. | |||
| [5] | China national comission of animal genetics resources. Animal genetics resource in China——Sheep and Goats. Beijing: China Agricultural Press, 2011. | |||
| [5] | 国家畜禽遗传资源委员会组编. 中国畜禽遗传资源志—羊志. 北京: 中国农业出版社, 2011. | |||
| [6] | Dong Y, Xie M, Jiang Y, Xiao N, Du X, Zhang W, Tosser-Klopp G, Wang J, Yang S, Liang J, Chen W, Chen J, Zeng P, Hou Y, Bian C, Pan S, Li Y, Liu X, Wang W, Servin B, Sayre B, Zhu B, Sweeney D, Moore R, Nie W, Shen Y, Zhao R, Zhang G, Li J, Faraut T, Womack J, Zhang Y, Kijas J, Cockett N, Xu X, Zhao S, Wang J, Wang W. Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nat Biotechnol, 2013, 31(2): 135-141. | |||
| [7] | Jiang Y, Xie M, Chen W, Talbot R, Maddox JF, Faraut T, Wu C, Muzny DM, Li Y, Zhang W, Stanton J-A, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SMJ, Adelson DL, Bian C, Cam GR, Chen Y, Cheng S, DeSilva U, Dixen K, Dong Y, Fan G, Franklin IR, Fu S, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang G, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu W, Liu X, Lu C, Lv T, Mathew T, McWilliam S, Menzies M, Pan S, Robelin D, Servin B, Townley D, Wang W, Wei B, White SN, Yang X, Ye C, Yue Y, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W, Dalrymple BP. The sheep genome illuminates biology of the rumen and lipid metabolism. Science, 2014, 344(6188): 1168-1173. | |||
| [8] | Kijas JW, Townley D, Dalrymple BP, Heaton MP, Maddox JF, McGrath A, Wilson P, Ingersoll RG, McCulloch R, McWilliam S, Tang D, McEwan J, Cockett N, Oddy VH, Nicholas FW, Raadsma H for the International Sheep Genomics Consortium. A genome wide survey of SNP variation reveals the genetic structure of sheep breeds. PLoS One, 2009, 4(3): e4668. | |||
| [9] | Tosser-klopp G, Bardou P, Bouchez O, Cabau C, Crooijmans R, Dong Y, Donnadieutonon C, Eggen A, Heuven HC, Jamli S, Jiken A, Klopp C, Lawley C, McEwan J, Martin P, Moreno C, Mulsant P, Nabihoudine I, Pa
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