The discovery and expansion of Hippo signaling pathway in <i>Drosophila</i> model

Shuguo Sun, Shian Wu, Lei Zhang,

doi:10.16288/j.yczz.17-051

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Hereditas(Beijing) >

2017 , Vol. 39 >Issue 7: 537 - 545

DOI: https://doi.org/10.16288/j.yczz.17-051

The discovery and expansion of Hippo signaling pathway in Drosophila model

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1. Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2. College of Life Science, Nankai University, Tianjin 300071, China
3. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

Received date: 2017-02-18

Revised date: 2017-04-02

Online published: 2017-05-03

Supported by

the Startup Foundation of Huazhong University of Science and Technology(2016020230)

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Abstract

The discovery of Hippo signaling pathway is another breakthrough of fly genetics. Similar to the other signaling pathways, Hippo pathway also functions crucially in tremendous physiological and pathological conditions, like organ size control and cancer. There are three main stages of Hippo pathway study: Firstly, identifications of core components by fly genetic screens; secondly, regulations by versatile upstream cues, like cytoskeleton, mechanical tension, and nutrition; thirdly, functions in different biological processes, like cell proliferation regulation, stem cell biology, and immunology. In this review, we summarize the current understanding of Hippo pathway and highlight its regulations and transcriptional complex assembly. We also discuss the potential future directions in Drosophila model system.

Key words： Hippo signaling pathway; Drosophila; organ size; cell growth

Cite this article

Shuguo Sun, Shian Wu, Lei Zhang, . The discovery and expansion of Hippo signaling pathway in Drosophila model[J]. Hereditas(Beijing), 2017 , 39(7) : 537 -545 . DOI: 10.16288/j.yczz.17-051

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