Hippo signaling pathway in lung development, regeneration, and diseases

Siling Fu,Wanying Zhao,Wenjing Zhang,Hai Song,Hongbin Ji,Nan Tang

doi:10.16288/j.yczz.17-056

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Hereditas(Beijing) >

2017 , Vol. 39 >Issue 7: 597 - 606

DOI: https://doi.org/10.16288/j.yczz.17-056

Review

Hippo signaling pathway in lung development, regeneration, and diseases

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1. National Institute of Biological Sciences, Beijing 102206, China
2. Graduate School of Peking Union Medical College, Beijing 100005, China
3. School of Life Science,Tsinghua University, Beijing 100084, China
4. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
5. School of Life Science, Zhejiang University, Hangzhou 310058, China

Received date: 2017-02-21

Revised date: 2017-03-22

Online published: 2017-05-31

Supported by

the National Basic Research Program of China(2014CB850003);the National Natural Science Foundation of China(31471368);the National Science Foundation for Distinguished Young Scholars(81325015)

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Abstract

The mammalian lung is essential for the gas exchange function between the circulation and the atmospheric environment. Lung diseases, including lung cancer, are among the leading causes of death in the modern society. Research on lung development, regeneration and cancer could provide significant insights for the development of therapeutic approaches on lung diseases. Hippo/YAP/TAZ signaling pathway regulates cell proliferation and differentiation, controls organ size, and plays an important role in response to mechanical forces. YAP/TAZ are expressed in many cell types and serve various regulatory functions in the embryonic and adult lungs. In this review, we mainly focus on the roles of Hippo/YAP/TAZ signaling pathway in embryonic lung development, regeneration and cancer. We postulate that Hippo/YAP/TAZ signaling may play potential roles in regulating the alveolar mechanics and immune responses in the lung.

Key words： Hippo signaling pathway; lung development and regeneration; lung cancer; lung fibrosis

Cite this article

Siling Fu,Wanying Zhao,Wenjing Zhang,Hai Song,Hongbin Ji,Nan Tang . Hippo signaling pathway in lung development, regeneration, and diseases[J]. Hereditas(Beijing), 2017 , 39(7) : 597 -606 . DOI: 10.16288/j.yczz.17-056

References

[1]

Zhao B, Li L, Lei QY, Guan KL. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev, 2010, 24(9): 862-874.

[2]

Zhao B, Tumaneng K, Guan KL. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol, 2011, 13(8): 877-883.

[3]

Yu FX, Guan KL. The Hippo pathway: Regulators and regulations. Genes Dev, 2013, 27(4): 355-371.

[4]

Chan EHY, Nousiainen M, Chalamalasetty RB, Sch?fer A, Nigg EA, Silljé HHW. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene, 2005, 24(12): 2076-2086.

[5]

Zhao B, Wei XM, Li WQ, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu JD, Li L, Zheng P, Ye KQ, Chinnaiyan A, Halder G, Lai ZC, Guan KL. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev, 2007, 21(21): 2747-2761.

[6]

Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol, 2008, 18(5): 311-321.

[7]

Dong JX, Feldmann G, Huang JB, Wu SA, Zhang NL, Comerford SA, Gayyed MF, Anders RA, Maitra A, Pan DJ. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell, 2007, 130(6): 1120-1133.

[8]

Oh H, Irvine KD. In vivo regulation of Yorkie phosphorylation and localization. Development, 2008, 135(6): 1081-1088.

[9]

Liu CY, Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, Li TT, Chan SW, Lim CJ, Hong WJ, Zhao SM, Xiong Y, Lei QY, Guan KL. The Hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF β-TrCP E3 ligase. J Biol Chem, 2010, 285(48): 37159-37169.

[10]

Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J, 2000, 19(24): 6778-6791.

[11]

Rawlins EL, Okubo T, Xue Y, Brass DM, Auten RL, Hasegawa H, Wang F, Hogan BLM. The role of Scgb1a1 + Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell, 2009, 4(6): 525-534.

[12]

Rock JR, Hogan BLM. Epithelial progenitor cells in lung development, maintenance, repair, and disease. Annu Rev Cell Dev Biol, 2011, 27(1): 493-512.

[13]

Desai TJ, Brownfield DG, Krasnow MA. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature, 2014, 507(7491): 190-194.

[14]

Barkauskas CE, Cronce MJ, Rackley CR, Bowie EJ, Keene DR, Stripp BR, Randell SH, Noble PW, Hogan BLM. Type 2 alveolar cells are stem cells in adult lun

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