The regulatory mechanisms and functional roles of the Hippo signaling pathway in breast cancer
Received date: 2017-03-23
Revised date: 2017-04-14
Online published: 2017-06-08
Supported by
the National Basic Research Program of China (973 Program)(2015CB910401);the National Natural Science Foundation of China(81430057,81572686)
Hippo signaling pathway has attracted broad attention due to its essential roles in controlling organ size and tumorigenesis. TAZ/YAP, two core downstream molecules of the Hippo signaling pathway in mammals, are tightly regulated by a wide range of extracellular and intrinsic signals in both Hippo signaling pathway-dependent and -independent manners. Besides their roles in the development and function of normal mammary glands, TAZ/YAP display remarkable potency and relevance to multiple aspects of human breast carcinogenesis, including cellular proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition and stemness. In this review, we summarize the regulators of TAZ/YAP, discuss the significant contribution of the Hippo signaling pathway to human breast cancers and highlight their potential therapeutic roles.
Key words： TAZ/YAP; Hippo signaling pathway; breast cancer
Chuanbo Yao, Xin Zhou, Ceshi Chen, Qunying Lei, . The regulatory mechanisms and functional roles of the Hippo signaling pathway in breast cancer[J]. Hereditas(Beijing), 2017 , 39(7) : 617 -629 . DOI: 10.16288/j.yczz.17-100
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