The roles and mechanisms of MST1/2 in the innate immune response
Received date: 2017-02-28
Revised date: 2017-03-22
Online published: 2017-06-28
Supported by
the National Natural Science Foundation of China(81571617, 31300723, 81671572, 31422018);the Strategic Priority Research Program of the Chinese Academy of Sciences Center for Excellence in Molecular Cell Science(XDB19000000);the Ministry of Science and Technology of China(2016YFD0500207, 2016YFC0902200)
The Hippo signaling pathway regulates cell proliferation, organ size and tissue regeneration through a series of kinase cascades. MST1/2 is the mammalian orthologue of the core kinase Hippo, which is crucial for the activation of downstream signaling. Additionally, MST1/2 has been reported to play important roles in cell differentiation, morphology and cytoskeleton reorganization. Recent evidence suggests that MST1/2 is involved in the regulation of T cell adhesion, migration, homing and Treg cell maturation and functions. Interestingly, these processes are not dependent on the canonical, but a non-canonical Hippo signaling pathway. More recent studies have revealed that MST1/2 mediates the innate immune response against pathogens or viruses, especially on macrophage phagocytosis as well as cytokines and ROS production. MST1/2 is associated with various diseases, such as bacterial or viral infection, inflammation-related cancer, and atherosclerosis. In this review, we summarize recent findings on the functions of MST1/2 in the innate immune response and inflammation-related diseases.
Xin Zhou,Weiyun Li,Hongyan Wang . The roles and mechanisms of MST1/2 in the innate immune response[J]. Hereditas(Beijing), 2017 , 39(7) : 642 -649 . DOI: 10.16288/j.yczz.17-066
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