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Hereditas(Beijing) >

2017 , Vol. 39 >Issue 11: 1066 - 1077

DOI: https://doi.org/10.16288/j.yczz.17-121

Orginal Article

Genetic and epigenetic regulation of PPARγ during adipogenesis

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  • 1. Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture, Harbin 150030, China
    2. Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China
    3. Key Laboratory of Animal Cells and Genetic Engineering of Heilongjiang Province, Harbin 150030, China

Received date: 2017-03-30

  Revised date: 2017-06-29

  Online published: 2017-12-20

Supported by

the National Natural Science Foundation of China(31572392,31372299);the China Agriculture Research System(CARS-42)

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Abstract

Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis and adipose tissue development. It also plays crucial roles in many other biological processes, including lipid and glucose metabolism and energy homeostasis. Recently, evidence has been accumulating that the PPARγ gene is not only genetically regulated, but also epigenetically regulated by DNA methylation, histone modification, non-coding RNA and chromosome remodeling. In this review, we summarize the advances in the genetic and epigenetic regulation of the PPARγ gene during adipogenesis, and discuss future research directions and trends for the study of its regulation.

Key words： PPARγ; adipogenesis; genetic regulation; epigenetic regulation; gene expression

Cite this article

Tingting Cui, Tianyu Xing, Yankan Chu, Hui Li, Ning Wang . Genetic and epigenetic regulation of PPARγ during adipogenesis[J]. Hereditas(Beijing), 2017 , 39(11) : 1066 -1077 . DOI: 10.16288/j.yczz.17-121

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