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Hereditas(Beijing) >

2017 , Vol. 39 >Issue 11: 1078 - 1089

DOI: https://doi.org/10.16288/j.yczz.17-130

Genome editing technologies drive the development of pig genetic improvement

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  • 1. State Key Lab of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    2. University of Chinese Academy of Sciences, Beijing 100101, China
    3. Company of Rongchang Breeding, Binzhou 251900, China

Received date: 2017-04-07

  Revised date: 2017-05-19

  Online published: 2017-12-20

Supported by

the National Natural Science Foundation of China(81671274, 31402045, 31601008);the National Science and Technology Major Project of the Ministry of Science and Technology of China(2016ZX08009003-006-007);the Strategic Pilot Program of the Chinese Academy of Sciences(XDA08010304)

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Abstract

Nuclease-mediated genome editing technologies contribute to the rapid advances in life sciences via the ability to edit the genomes within living cells, and present a new era for porcine genetic improvement. In this review, we introduce the development of various genomic editing technologies, particularly CRISPR/Cas9 strategies and characteristics of various naturally occurring and artificially engineered CRISPR enzymes. Also, we summarize progress in pig genetic improvement mediated by genome editing, especially those associated with meat quality traits and anti-virus resistance. We highlight the challenges in the implementation of pig genetic improvement and the prospects of pig genetic breeding based on genome editing technologies.

Key words： pig; genomic editing; genetic improvement

Cite this article

Jiaojiao Huang, Chunwei Cao, Guomin Zheng, Jianguo Zhao . Genome editing technologies drive the development of pig genetic improvement[J]. Hereditas(Beijing), 2017 , 39(11) : 1078 -1089 . DOI: 10.16288/j.yczz.17-130

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