Progress of GATA6 in liver development
Received date: 2017-05-08
Revised date: 2017-12-13
Online published: 2017-12-27
Supported by
the National Undergraduate Innovation and Entrepreneurship Training Program of China(201610635068);Fundamental Research Funds for the Central Universities(XDJK2015B011)
GATA binding protein 6 (GATA6) is a member of the GATA family of zinc-finger transcriptional regulators, whose names come from the conservative base sequence (G/A)GATA(A/T). The GATA families play key roles in cell fate determination, proliferation, migration, and organogenesis of endoderm- and mesoderm-derived organs in vertebrates. As a lineage-specific factor, a chromatin remodeling factor, a pluripotent factor and a pioneer factor, GATA6 is involved in various stages of liver development, including endoderm liver-lineage determination, liver specification, hepatic bud outgrowth and hepatoblast differentiation. In this review, we summarize recent progress in the roles and regulatory mechanisms of GATA6 in liver development.
Key words： GATA6; liver development; transcription factor; pioneer factor; reprogramming
Ling Zhang, Jianbo He . Progress of GATA6 in liver development[J]. Hereditas(Beijing), 2018 , 40(1) : 22 -32 . DOI: 10.16288/j.yczz.17-163
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