The critical roles of TBC proteins in human diseases

Mengting Shi, Ying Zhang, Gangqiao Zhou

doi:10.16288/j.yczz.17-343

[an error occurred while processing this directive]

Hereditas(Beijing) >

2018 , Vol. 40 >Issue 1: 12 - 21

DOI: https://doi.org/10.16288/j.yczz.17-343

Review

The critical roles of TBC proteins in human diseases

Expand

1. Graduate School, Guangxi Medical University, Nanning 530021, China
2. National Center for Protein Sciences, the State Key Lab of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China

Received date: 2017-10-22

Revised date: 2017-12-12

Online published: 2017-12-22

Supported by

the National Science Foundation of China(81401981)

Fold

Abstract

The Tre-2/Bub2/Cdc16 (TBC) domain is a conserved protein motif consisting of approximately 200 amino acids, and is present in many eukaryotic proteins. TBC domain-containing proteins (TBC proteins) function as GTPase activating proteins (GAPs) for the small GTPase Rab, which can promote the hydrolysis of Rab-GTP to Rab-GDP in regulation of specific intracellular trafficking pathways. Several TBC proteins play important roles in cellular functions in mammals, and defects of which are closely associated with numerous disease processes. In this review, we summarize the structures and functions of the mammalian TBC proteins and recent advances in understanding their critical roles in the development of human diseases. This review serves as a reference for further investigations on the functions of TBC proteins in disease pathogeneses.

Key words： Rab; TBC; GTPase activating protein; trafficking

Cite this article

Mengting Shi, Ying Zhang, Gangqiao Zhou . The critical roles of TBC proteins in human diseases[J]. Hereditas(Beijing), 2018 , 40(1) : 12 -21 . DOI: 10.16288/j.yczz.17-343

References

[1]

Tzeng HT, Wang YC. Rab-mediated vesicle trafficking in cancer. J Bio Med, 2016, 23(1): 70.

[2]

Richardson PM, Zon LI. Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16. Oncogene, 1995, 11(6): 1139-1148.

[3]

Pan X, Eathiraj S, Munson M, Lambright DG. TBC- domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism. Nature, 2006, 442(7100): 303-306.

[4]

Chen YN, Gu X, Zhou XE, Wang W, Cheng D, Ge Y, Ye F, Xu HE, Lv Z. Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases. Protein Sci, 2017, 26(4): 834-846.

[5]

Frasa MA, Maximiano FC, Smolarczyk K, Francis RE, Betson ME, Lozano E, Goldenring J, Seabra MC, Rak A, Ahmadian MR. Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation. Curr Biol, 2010, 20(3): 198-208.

[6]

Kanno E, Ishibashi K, Kobayashi H, Matsui T, Ohbayashi N, Fukuda M. Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs. Traffic, 2010, 11(4): 491-507.

[7]

Eitzen G, Will E, Gallwitz D, Haas A, Wickner W. Sequential action of two GTPases to promote vacuole docking and fusion. EMBO J, 2000, 19(24): 6713-6720.

[8]

Brett CL, Plemel RL, Lobingier BT, Vignali M, Fields S, Merz AJ. Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase. J Cell Biol, 2008, 182(6): 1141-1151.

[9]

Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature, 2000, 408(6810): 374-377.

[10]

Fuchs E, Haas AK, Spooner RA, Yoshimura S, Lord JM, Barr FA. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol, 2007, 177(6): 1133-1143.

[11]

Haas AK, Fuchs E, Kopajtich R, Barr FA. A GTPase-activating protein controls Rab5 function in endocytic trafficking. Nat Cell Biol, 2005, 7(9): 887-893.

[12]

Meyre D, Farge M, Lecoeur C, Proenca C, Durand E, Allegaert F, Tichet J, Marre M, Balkau B, Weill J, Delplanque J, Froguel P. R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population. Hum Mol Genet, 2008, 17(12): 1798-1802.

[13]

Peck GR, Chavez JA, Roach WG, Budnik BA, Lane WS, Karlsson HK, Zierath JR, Lienhard GE. Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J Biol Chem, 2009, 284(44): 30016-30023.

〈

〉

www.chinagene.cn
备案号：京ICP备09063187号

模态框（Modal）标题

Abstract

Cite this article

References