Research progress in sRNAs and functional proteins in epididymosomes

Juan Xiao, Xun Wang, Yi Luo, Xiaokai Li, Xuewei Li

doi:10.16288/j.yczz.17-148

[an error occurred while processing this directive]

Hereditas(Beijing) >

2018 , Vol. 40 >Issue 3: 197 - 206

DOI: https://doi.org/10.16288/j.yczz.17-148

Reviews

Research progress in sRNAs and functional proteins in epididymosomes

Expand

College of Animal Science and Technology, Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China

Received date: 2017-09-15

Revised date: 2018-01-29

Online published: 2018-02-05

Supported by

[Supported by the Application Basic Research Plan Project of Sichuan Province (No.2016JY0167), the Key Project of Sichuan Education Department (No.15ZA0008), the Program for Innovative Research Team of Sichuan Province (No.2015TD0012) and the Specialized Research Fund of Ministry of Agriculture of China(No.NYCYTX-009)]

Fold

Abstract

The semen quality is a basic and the most important indicator of male reproductive health. Mammalian spermatozoa undergo a series of complex structural and functional changes in the epididymis to mature and achieve fertilization capacity. Sperm cell maturation is mediated by a complex physiological process, which is synergistically regulated by a large number of transcription factors, hormones and other signaling molecules. In recent years, there is increasing evidence supporting the notion that functional proteins and sRNA (small RNAs) in epididymosomes participate in sperm maturation and fertilization process. In this review, we summarize the biological roles of functional proteins and two major sRNAs (tRNAs and miRNAs) in sperm maturation in epididymosomes, and provide some theoretical guidance and new ideas for treatments of low fertility, infertility and other reproductive diseases in men.

Key words： semen; exosome; epididymosomes; protein; miRNA; tsRNA

Cite this article

Juan Xiao, Xun Wang, Yi Luo, Xiaokai Li, Xuewei Li . Research progress in sRNAs and functional proteins in epididymosomes[J]. Hereditas(Beijing), 2018 , 40(3) : 197 -206 . DOI: 10.16288/j.yczz.17-148

References

[1]

Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, Carson SA, Cisneros P, Steinkampf MP, Hill JA, Xu D, Vogel DL . Sperm morphology, motility, and concentration in fertile and infertile men. New Engl J Med, 2001,345(19):1388-1393.

[2]

Dacheux J, Voglmayr J . Sequence of sperm cell surface differentiation and its relationship to exogenous fluid proteins in the ram epididymis. Biol Reprod, 1983,29(4):1033-1046.

[3]

Gatti JL, Castella S, Dacheux F, Ecroyd H, Métayer S, Thimon V, Dacheux JL. Post-testicular sperm environment and fertility. Anim Reprod Sci, 2004, 82-83:321-339.

[4]

Caballero J, Frenette G, Sullivan R . Post testicular sperm maturational changes in the bull: important role of the epididymosomes and prostasomes. Vet Med Int, 2010,2011:757194.

[5]

Yanagimachi R, Kamiguchi Y, Mikamo K, Suzuki F, Yanagimachi H . Maturation of spermatozoa in the epididymis of the Chinese hamster. Devel Dyn, 1985,172(4):317-330.

[6]

Sullivan R, Saez F, Girouard J, Frenette G . Role of exosomes in sperm maturation during the transit along the male reproductive tract. Blood Cell Mol Dis, 2005,35(1):1-10.

[7]

Sullivan R, Saez F . Epididymosomes, prostasomes, and liposomes: their roles in mammalian male reproductive physiology. Reproduction, 2013,146(1):R21-R35.

[8]

Sullivan R, Frenette G, Girouard J . Epididymosomes are involved in the acquisition of new sperm proteins during epididymal transit. Asian J Androl, 2007,9(4):483-491.

[9]

Martin-DeLeon PA . Epididymosomes: transfer of fertility- modulating proteins to the sperm surface. Asian J Androl, 2015,17(5):720-725.

[10]

Bajpai V, Shipstone A, Ratna KB, Qaisar J, Setty B . Ultrastructure of the epididymal epithelium of rhesus monkey (Macaca mulatta). Acta Eur Fertil, 1984,16(3):207-217.

[11]

AGRAWAL Y, VANHA-PERTTULA T . Electron microscopic study of the secretion process in bovine reproductive organs. J Androl, 1988,9(5):307-316.

[12]

Frenette G, Lessard C, Sullivan R . Selected proteins of “prostasome-like particles” from epididymal cauda fluid are transferred to epididymal caput spermatozoa in bull. Biol Reprod, 2002,67(1):308-313.

[13]

Frenette G, Sullivan R . Prostasome-like particles are involved in the transfer of P25b from the bovine epididymal fluid to the sperm surface. Mol Reprod Dev, 2001,59(1):115-121.

[14]

Hermo L, Adamali HI, Andonian S . Immunolocalization of CA II and H^+ V-ATPase in epithelial cells of the mouse and rat epididymis. J Androl, 2000,21(3):376-391.

[15]

Fornés M, Barbieri A, Cav

Options

Outlines

〈

〉

www.chinagene.cn
备案号：京ICP备09063187号

模态框（Modal）标题

Abstract

Cite this article

References