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Hereditas(Beijing) >

2018 , Vol. 40 >Issue 9: 724 - 732

DOI: https://doi.org/10.16288/j.yczz.18-050

Reviews

MicroRNA regulates Sertoli cell proliferation and adhesion

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  • Department of Histology and Embryology, School of Medicine,Yangzhou University, Yangzhou 225001, China

Received date: 2018-02-27

  Revised date: 2018-06-26

  Online published: 2018-07-27

Supported by

Supported by the National Natural Science Foundation of China(31371174);the Natural Science Foundation of Jiangsu Province(BK20131230)

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Abstract

Spermatogenesis requires both germ cells and testicular somatic cells, which are also involved in testicular development and male fertility. Sertoli cells are the only somatic cells in the seminiferous tubules and play very important roles in normal spermatogenesis. Abnormality of Sertoli cells in proliferation and adhesion may induce aberrant spermatogenesis and eventually cause infertility. Recently, various studies have demonstrated that miRNA are involved in the regulation of Sertoli cell proliferation and adhesion. Additionally, miRNA expression could be affected by hormone, endocrine interferon, and nutrition. In this review, we summarize miRNAs related to Sertoli cell proliferation and adhesion, which will be helpful for finding and identifying more miRNAs from Sertoli cells. The review will also provide theoretical basis for the pathogenesis of infertility associated with Sertoli cells.

Key words： miRNA; Sertoli cells; proliferation; adhension

Cite this article

Xia Mengmeng,Shen Xueyi,Niu Changmin,Xia Jing,Sun Hongya,Zheng Ying . MicroRNA regulates Sertoli cell proliferation and adhesion[J]. Hereditas(Beijing), 2018 , 40(9) : 724 -732 . DOI: 10.16288/j.yczz.18-050

References

[1] Hai Y, Hou J, Liu Y, Liu Y, Yang H, Li Z, He Z . The roles and regulation of Sertoli cells in fate determinations of spermatogonial stem cells and spermatogenesis. Semin Cell Dev Biol, 2014,29:66-75.
[2] Chen SR, Liu YX . Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling. Reproduction, 2015,149(4):R159-R167.
[3] Auharek SA, de Fran?a LR . Postnatal testis development, Sertoli cell proliferation and number of different spermatogonial types in C57BL/6J mice made transiently hypo- and hyperthyroidic during the neonatal period. J Anat, 2010,216(5):577-588.
[4] Escott GM, da Rosa LA, Loss Eda S . Mechanisms of hormonal regulation of sertoli cell development and proliferation: a key process for spermatogenesis. Curr Mol Pharmacol, 2014,7(2):96-108.
[5] Li L, Gao Y, Chen H, Jesus T, Tang E, Li N, Lian Q, Ge RS, Cheng CY . Cell polarity, cell adhesion, and spermatogenesis: role of cytoskeletons. F1000Res, 2017,6:1565.
[6] Papaioannou MD, Pitetti JL, Ro S, Park C, Aubry F, Schaad O, Vejnar CE, Kühne F, Descombes P, Zdobnov EM, McManus MT, Guillou F, Harfe BD, Yan W, Jégou B, Nef S . Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol, 2009,326(1):250-259.
[7] Ma C, Song H, Yu L, Guan K, Hu P, Li Y, Xia X, Li J, Jiang S, Li F . MiR-762 promotes porcine immature Sertoli cell growth via the ring finger protein 4 (RNF4) gene. Sci Rep, 2016,6:32783.
[8] Hu P, Guan K, Feng Y, Ma C, Song H, Li Y, Xia X, Li J, Li F . MiR-638 inhibits immature Sertoli cell growth by indirectly inactivating PI3K/AKT pathway via SPAG1 gene. Cell Cycle, 2017,16(23):2290-2300.
[9] Yao C, Sun M, Yuan Q, Niu M, Chen Z, Hou J, Wang H, Wen L, Liu Y, Li Z, He Z . MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3. Oncotarget, 2016,7(3):2201-2219.
[10] Yin X, Ma T, Han R, Ding J, Zhang H, Han X, Li D . MiR-301b-3p/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)-induced proliferation by targeting Rasd1 in Sertoli cells. Toxicol In Vitro, 2017,47:79-88.
[11] Jiao ZJ, Yi W, Rong YW, Kee JD, Zhong WX . MicroRNA-1285 regulates 17beta-estradiol-inhibited immature boar Sertoli cell proliferation via adenosine monophosphate-activated protein kinase activation. Endocrinology, 2015,156(11):4059-4070.
[12] Panneerdoss S, Chang YF, Buddavarapu KC, Chen HI, Shetty G, Wang H, Chen Y, Kumar TR, Rao MK . Androgen-responsive microRNAs in mouse Sertoli cells. PLoS One, 2012,7(7):e41146.
[13] Panneerdoss S, Viswanadhapalli S, Abdelfattah N, Onyeagucha BC, Timilsina S, Mohammad TA, Chen Y, Drake M, Vuori K, Kumar TR, Rao MK . Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis
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