Chromosome structural variations disturb the inherent balance system, affecting biological reproduction and development. It has been a long standing question that teachers often face in undergraduate genetics teaching as to how to further interpret the underlying mechanisms that cause the disorder of the balance system. Some chimeric genes are the products of chromosome structure variation and have specific biological functions. They may cause the disorder of the inherent balance system. However, chimeric genes are rarely described in the classroom or textbook. We designed a teaching plan based on our researching experience of chimeric genes and teaching practice in genetics in recent years. First, we used a lawsuit to introduce chimeric genes for simulating students' learning interest, and then summarized the prevalence of chimeric genes for developing students' thinking. Finally, we hope to make students deeply understand genetic variation and improve genetics teaching.