Research advances on molecular regulation of filamentous fungal secondary metabolism in China
Received date: 2018-06-22
Revised date: 2018-08-23
Online published: 2018-09-10
Supported by
the National Natural Science Foundation of China(31470177);the National Natural Science Foundation of China(31770056)
More than half of the activity secondary metabolites from microorganisms are produced by filamentous fungi. The metabolites that are well known include penicillin, cyclosporine A, lovastatin, and so on. Due to their importance in agriculture, medicine and industry, biosynthesis and regulation of these fungal secondary metabolites have attracted much attention. The biosynthesis of fungal secondary metabolites is a complex process which generally includes multistep enzymatic reactions. Commonly, the process is controlled by elaborate regulations at different levels. A good understanding of the molecular regulation of fungal secondary metabolism will lay a theoretical foundation for improving metabolite production, mining novel compounds and activating the silent gene clusters. In this review, we focus on molecular regulation of filamentous fungal secondary metabolite biosynthesis, especially the research advances of Chinese scientists in recent forty years are mainlyintroduced. Finally, we propose the future challenges and opportunities in this field.
Key words： China; filamentous fungi; molecular regulation; secondary metabolism
Yuanyuan Pan, Gang Liu . Research advances on molecular regulation of filamentous fungal secondary metabolism in China[J]. Hereditas(Beijing), 2018 , 40(10) : 874 -887 . DOI: 10.16288/j.yczz.18-169
| [1] | Bok JW, Keller NP . LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell, 2004,3(2):527-535. |
| [2] | Wang YP, Tan YM, Zhou GQ, Lan Y, Liu YX, Luo Z, Liu ZY . Recent advances of global regulator LaeA of filamentous fungi. Genomics and Applied Biology, 2017,36(2):712-718. |
| [2] | 王亚萍, 谭玉梅, 周国庆, 兰亚, 刘永翔, 罗钊, 刘作易 . 丝状真菌全局性调控因子LaeA的研究进展. 基因组学与应用生物学, 2017,36(2):712-718. |
| [3] | Bok JW, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Keller NP . LaeA, a regulator of morphogenetic fungal virulence factors. Eukaryot Cell, 2005,4(9):1574-1582. |
| [4] | Jiang T, Wang M, Li L, Si J, Song B, Zhou C, Yu M, Wang X, Zhang Y, Ding G, Zou Z . Overexpression of the global regulator LaeA in Chaetomium globosum leads to the biosynthesis of Chaetoglobosin Z. J Nat Prod, 2016,79(10):2487-2494. |
| [5] | Zheng Y, Cao S, Huang Y, Liao G, Hu C . Overexpression of LaeA enhances mevastatin production and reduces sporulation of Penicillium citrinum. Acta Microbiol Sin, 2014,54(12):1438-1445. |
| [6] | Zhou F . The research of the proteins interacting with the global regulator, LaeA in the Pennicillium citrinum. [Dissertation]. Southwest University, 2014. |
| [6] | 周峰 . 橘青霉全局性调控因子LaeA相互作用蛋白研究 [学位论文]. 西南大学, 2014. |
| [7] | Zhang X, Zhu Y, Bao L, Gao L, Yao G, Li Y, Yang Z, Li Z, Zhong Y, Li F, Yin H, Qu Y, Qin Y . Putative methyltransferase LaeA and transcription factor CreA are necessary for proper asexual development and controlling secondary metabolic gene cluster expression. Fungal Genet Biol, 2016,94:32-46. |
| [8] | Liu Q, Cai L, Shao Y, Zhou Y, Li M, Wang X, Chen F . Inactivation of the global regulator LaeA in Monascus ruber results in a species-dependent response in sporulation and secondary metabolism. Fungal Biol, 2016,120(3):297-305. |
| [9] | Lv YY . Study on regulation of secondary metabolism in Aspergillus niger FGSC A1279 [Dissertation]. South China University of Technology, 2014. |
| [9] | 吕扬勇 . 黑曲霉FGSC A1279次级代谢调控研究[学位论文]. 华南理工大学, 2014. |
| [10] | Wang B, Lv YY, Li XJ, Lin YY, Deng H, Pan L . Profiling of secondary metabolite gene clusters regulated by LaeA in Aspergillus niger FGSC A1279 based on genome sequencing and transcriptome analysis. Res Microbiol, 2018,169(2):67-77. |
| [11] | Akhberdi O, Zhang Q, Wang D, Wang H, Hao X, Liu Y, Wei D, Zhu X . Distinct roles of velvet complex in the development, stress tolerance, and secondary metabolism in Pestalotiopsis microspora, a taxol producer. Genes, 2018,9(3):164. doi: 10.3390/genes9030164. |
| [12] |