[an error occurred while processing this directive]

Hereditas(Beijing) >

2019 , Vol. 41 >Issue 2: 125 - 136

DOI: https://doi.org/10.16288/j.yczz.18-293

Reviews

The role of actin cytoskeleton in regulating the deployment process of mouse cardiac second heart field progenitor cells

Expand
  • College of Life Science and Health, Wuhan University of Science and Technology, Wuhan 430065, China

Received date: 2018-10-29

  Revised date: 2019-01-18

  Online published: 2019-01-29

Supported by

[Supported by the National Natural Science Foundation of China ](31701266)

Fold

Abstract

The vertebrate heart tube originates from cardiogenic mesodermal cells in the early embryo, and subsequently elongates by progressive addition of second heart field (SHF) progenitor cells from adjacent pharyngeal mesoderm and splanchnic mesoderm. Insufficient addition of SHF cells to the heart tube causes the failure of maximal elongation of the heart tube, which results in a series of developmental defects including the most common congenital birth defects, such as right ventricular dysplasia and outflow tract septation, and alignment anomalies. SHF cells form an atypical, apicobasally polarized epithelium which is characterized by apical monocilia, and dynamic actin-rich basal filopodia. In this review, we summarize recent research progresses of actin cytoskeleton in the deployment process of mouse SHF progenitor cells, and reveal the significance of actin cytoskeleton in SHF development, especially in the deployment of SHF cells to the outflow tract, to provide theoretical reference for elucidating and understanding the biological characteristics of SHF deployment.

Key words： actin; second heart field; cell deployment; mouse

Cite this article

Zhongying Liu,Xia Huang,Ziyi Li,Zihao Yang,Baiyin Yuan . The role of actin cytoskeleton in regulating the deployment process of mouse cardiac second heart field progenitor cells[J]. Hereditas(Beijing), 2019 , 41(2) : 125 -136 . DOI: 10.16288/j.yczz.18-293

References

[1] Bruneau BG . The developmental genetics of congenital heart disease. Nature, 2008,451(7181):943-948. [DOI]
[2] Vincent SD, Mayeuf-Louchart A, Watanabe Y, Brzezinski JA IV, Miyagawa-Tomita S, Kelly RG, Buckingham M . Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with tbx1, during outflow tract morphogenesis in the mouse embryo. Hum Mol Genet, 2014,23(19):5087-5101. [DOI]
[3] Evans SM, Yelon D, Conlon FL, Kirby ML . Myocardial lineage development. Circ Res, 2010,107(12):1428-1444. [DOI]
[4] Buckingham M, Meilhac S, Zaffran S . Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet, 2005,6(11):826-835. [DOI]
[5] Vincent SD, Buckingham ME . How to make a heart: The origin and regulation of cardiac progenitor cells. Curr Top Dev Biol, 2010,90:1-41. [DOI]
[6] Dyer LA, Kirby ML . The role of secondary heart field in cardiac development. Dev Biol, 2009,336(2):137-144. [DOI]
[7] Sinha T, Li D, Théveniau-Ruissy M, Hutson MR, Kelly RG, Wang J . Loss of wnt5a disrupts second heart field cell deployment and may contribute to oft malformations in digeorge syndrome. Hum Mol Genet, 2015,24(6):1704-1716. [DOI]
[8] Sinha T, Wang B, Evans S, Wynshaw-Boris A, Wang J . Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis. Dev Biol, 2012,370(1):135-144. [DOI]
[9] Francou A, Saint-Michel E, Mesbah K, Kelly RG . Tbx1 regulates epithelial polarity and dynamic basal filopodia in the second heart field. Development, 2014,141(22):4320-4331. [DOI]
[10] Kelly RG . The second heart field. Curr Top Dev Biol, 2012,100:33-65. [DOI]
[11] van den Berg G, Abu-Issa R, de Boer BA, Hutson MR, de Boer PA, Soufan AT, Ruijter JM, Kirby ML, van den Hoff MJ, Moorman AF . A caudal proliferating growth center contributes to both poles of the forming heart tube. Circ Res, 2009,104(2):179-188. [DOI]
[12] Mesbah K, Harrelson Z, Théveniau-Ruissy M, Papaioannou VE, Kelly RG . Tbx3 is required for outflow tract development. Circ Res, 2008,103(7):743-750. [DOI]
[13] Cortes C, Francou A, De Bono C, Kelly RG . Epithelial properties of the second heart field. Circ Res, 2018,122(1):142-154. [DOI]
[14] de la Cruz MV, Sánchez Gómez C, Arteaga MM, Argüello C . Experimental study of the development of the truncus and the conus in the chick embryo. J Anat, 1977,123(Pt 3):661-686. [DOI]
[15] Viragh S, Challice CE . Origin and differentiation of cardiac muscle cells in the mouse. J Ultrastruct Res, 1973,
Options
Outlines

/

〈 〉

www.chinagene.cn
备案号：京ICP备09063187号

版权所有 © 中国科学院遗传与发育生物学研究所 中国遗传学会
地址：北京市朝阳区北辰西路1号院　中国科学院遗传与发育生物学研究所2号楼B-208　
邮政编码：100101
联系电话：010-64807669
E-mail：yczz@genetics.ac.cn