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Hereditas(Beijing) >

2019 , Vol. 41 >Issue 5: 404 - 412

DOI: https://doi.org/10.16288/j.yczz.19-042

Review

Advances in m 6A modification and its regulation of viral replication

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  • 1. Jiangsu Key Laboratory of Sericutural Biology and Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212018, China
    2. Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agriculture, Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang 212018, China

Received date: 2019-02-20

  Revised date: 2019-04-08

  Online published: 2019-04-16

Supported by

National Natural Science Foundation of China(31672490);Natural Science Foundation of Jiangsu Province(BK20151322);Major Project of Natural Science Foundation for Universities of Jiangsu Province(15KJA180001)

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Abstract

N 6-methyladenosine (m 6A) is a prevalent modification of RNA in eukaryotes and plays an important role in the process of mRNA translocation, stabilization and translation. m 6A exerts different influences on the viral replication cycle, and both viral replication and host immune response to the virus are affected by m 6A. In this review, we summarize recent studies on the mechanism of m 6A modification and its effects on viral replication and host immune response, in order to provide a reference for epigenetic regulation in the viral life cycle.

Key words： N 6-methyladenosine; RNA modification; virus; replication; immunity

Cite this article

Peng Xue, Tao Jiang, Xingjia Shen . Advances in m 6A modification and its regulation of viral replication[J]. Hereditas(Beijing), 2019 , 41(5) : 404 -412 . DOI: 10.16288/j.yczz.19-042

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