Schizophrenia-associated single nucleotide polymorphisms affecting microRNA function
Received date: 2019-05-08
Revised date: 2019-07-07
Online published: 2019-08-05
Supported by
Supported by the Guangdong Science and Technology Foundation(2019B030316032);The Guangzhou Science and Technology Foundatio(201804010259);The National Natural Science Foundation of China(81601175);The National Natural Science Foundation of China(81671333)
MicroRNAs (miRNAs) compose a class of non-coding transcripts with a mean length of 22 nucleotides, and play critical roles in regulating gene expression in the process of development, proliferation and differentiation of neurons. Recent genome-wide association studies (GWAS) find most of schizophrenia-associated single nucleotide polymorphisms (SNPs) locating in the non-coding regions, providing functional implications of miRNAs in the development of schizophrenia. In this review, we highlight the interplays between GWAS-SNPs and miRNAs in four perspectives: SNP in miRNA gene; miRNA located in the host gene; SNP located in the miRNA’s seed sequence; SNP located in the miRNA’s binding site. We also speculate on the future research on the role of miRNA in the development of schizophrenia.
Key words： GWAS; SNP; miRNA; schizophrenia
Wenquan Liang,Yu Hou,Cunyou Zhao . Schizophrenia-associated single nucleotide polymorphisms affecting microRNA function[J]. Hereditas(Beijing), 2019 , 41(8) : 677 -685 . DOI: 10.16288/j.yczz.19-126
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