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Hereditas(Beijing) >

2019 , Vol. 41 >Issue 9: 816 - 826

DOI: https://doi.org/10.16288/j.yczz.19-134

Review

Advances in the study of ovarian dysfunction with aging

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  • 1. Reproductive Medicine Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
    2. Center for Clinical Stem Cell Research, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
    3. State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100190, China

Received date: 2019-06-28

  Revised date: 2019-07-16

  Online published: 2019-08-11

Supported by

Supported by the National Key Research and Development Program of China No.(2018YFC1004700);The Strategic Priority Research Program of the Chinese Academy of Sciences No(XDA01030501)

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Abstract

Societal changes regarding the role of women have significant impacts on women’s willingness and the timing of childbearing. Ovarian reserve in woman typically begins to decline at the age of 35, and it is primarily characterized by a reduction in the number of ovarian follicles and a decline in oocyte quality. The clinical diagnosis of ovarian insufficiency relies on multiple variables including changes of follicle stimulating hormone (FSH), serum anti-Müllerian hormone (AMH), inhibin B, antral follicle count, menstruation and age. It is proven that ovarian cells demonstrate dysfunction associated with aging including mitochondrial dysfunction, telomere shortening, impaired DNA repair, epigenetic changes and metabolic/energetic disorders. In this review, we introduce the clinical diagnosis and management of ovarian insufficiency. We mainly discuss the molecular mechanism and potential interventions. We are optimistic that this information and knowledge will inform the important decisions for women and society regarding childbearing.

Key words： ovarian; aging; mitochondrion; heredity; epigenomics

Cite this article

Chuanming Liu,Lijun Ding,Jiayin Li,Jianwu Dai,Haixiang Sun . Advances in the study of ovarian dysfunction with aging[J]. Hereditas(Beijing), 2019 , 41(9) : 816 -826 . DOI: 10.16288/j.yczz.19-134

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