Linking chromatin conformation to gene function
Received date: 2019-08-29
Revised date: 2019-10-29
Online published: 2019-12-04
Supported by
Supported by the Agricultural Science and Technology Innovation Program, the Thousand Talents Plan for Young Professionals, the Fundamental Research Funds for Central Non-profit Scientific Institution No(Y2019PT18-02);the National Natural Science Foundation of China No(31970592);the National Key R&D Program of China No(2018YFA0903201)
DNA is highly compressed and packaged as chromatin within the nucleus in eukaryotes. DNA replication, DNA repair and transcription, and other biological processes are precisely regulated or determined by chromatin conformation. Activation or repression of different genes/transcription factors are tightly correlated to their chromatin conformation which contributes to cell self-maintenance, differentiation, specificity and identity. Therefore, the study of bridging chromatin conformation to gene function has became crucial for decoding genetic information and precision biology which is also a great challenge for current genomics research. Here, we review the multiple aspects of chromatin conformation, including its history, characteristics, dynamics and the impact on different dimension-chromatin architecture to gene function. Additionally, we discuss the limitation and challenges of current status of linking chromatin conformation to gene function study. We believe this is informative and foundational in combing the context between chromatin conformation and gene function as reference.
Key words： chromatin conformation; gene function; dynamic regulation
Qitong Huang, Qing Li, Yubo Zhang . Linking chromatin conformation to gene function[J]. Hereditas(Beijing), 2020 , 42(1) : 1 -17 . DOI: 10.16288/j.yczz.19-257
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