Molecular regulation mechanism of Myomaker and Myomerger in myoblast fusion
Received date: 2019-08-08
Revised date: 2019-10-25
Online published: 2019-12-05
Supported by
Supported by Research and Development Project of Scientific and Technological Cooperation between Sichuan Provincial Colleges and Universities No(2017JZ0025);the Science and Technology Support Program of Sichuan Nos(2016NYZ0042);the Science and Technology Support Program of Sichuan Nos.(2017NZDZX0002);Chongqing Agricultural Development Foundation Nos(12404);Chongqing Agricultural Development Foundation Nos(17430);the Key Research and Development Projects of Sichuan Science and Technology Department No(2019YFN0035)
Myogenesis is a complex physiological process that is mainly involved in the proliferation of myogenic stem cells to form myoblasts, which then differentiated and fused to form multinucleated myotubes. Many proteins have been found to be involved in myoblast fusion, but none of them are muscle-specific fusion proteins. In recent years, two muscle-specific transmembrane proteins, i.e. Myomaker and Myomerger, have been discovered and identified, which can coordinate and promote the fusion of myoblasts and thus participate in the process of myogenesis. In this review, we summarize the research progress of Myomaker and Myomerger in myogenesis, including their expression patterns and functional domains, as well as their participation in myoblast fusion mechanisms, aiming to provide relevant ideas for in-depth study of the myogenesis process and treatment of diseases related to myoblast fusion.
Key words： myogenesis; Myomaker; Myomerger; myoblast fusion
Yan Zhu, Jinwei Zhang, Jing Qi, Xuewei Li, Lei Chen, Mingzhou Li, Jideng Ma . Molecular regulation mechanism of Myomaker and Myomerger in myoblast fusion[J]. Hereditas(Beijing), 2019 , 41(12) : 1110 -1118 . DOI: 10.16288/j.yczz.19-232
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